Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
1998-3-19
pubmed:abstractText
Multiple sclerosis (MS) is a neurological, demyelinating disorder with a putative autoimmune etiology. It is thought to be a multifactorial disease with a complex mode of inheritance. Here we report the results of a two-stage genomewide scan for loci predisposing to MS. The first stage of the screen, with a low-resolution map, was performed in a selection of 16 pedigrees collected from an isolated Finnish population. Multipoint, non-parametric linkage analysis of the 328 markers did not reveal statistically significant results. However, 10 slightly interesting regions (P = .1-.15) emerged, including our previous findings of the HLA complex on 6p21 and a putative locus on 5p14-p12. Eight of these novel regions were further analyzed by use of denser marker maps, in the second stage of the scan. For the chromosomal regions 4cen, 11tel, and 17q, the statistical significance increased, but not conclusively; for 2q32 and 10q21, the statistical significance did not change. Accordingly, genotyping of the high-density markers in these regions was performed, and the data were analyzed by use of two-point, parametric linkage analysis using the complete pedigree information of the 21 Finnish multiplex families. We detected suggestive evidence for a predisposing locus on chromosomal region 17q22-q24. Several markers on 17q22-q24 yielded positive LOD scores, with the maximum LOD score (Zmax) occurring with D17S807 (Zmax = 2.8, theta = .04; dominant model). Interestingly, a suggestive linkage between MS and the markers on 17q22-q24 was also revealed by a recent genomewide scan in MS families from the United Kingdom.
pubmed:grant
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/9399895-1146497, http://linkedlifedata.com/resource/pubmed/commentcorrection/9399895-1383661, http://linkedlifedata.com/resource/pubmed/commentcorrection/9399895-1431951, http://linkedlifedata.com/resource/pubmed/commentcorrection/9399895-1672869, http://linkedlifedata.com/resource/pubmed/commentcorrection/9399895-1683213, http://linkedlifedata.com/resource/pubmed/commentcorrection/9399895-1926129, http://linkedlifedata.com/resource/pubmed/commentcorrection/9399895-2562801, http://linkedlifedata.com/resource/pubmed/commentcorrection/9399895-2567636, http://linkedlifedata.com/resource/pubmed/commentcorrection/9399895-3376997, http://linkedlifedata.com/resource/pubmed/commentcorrection/9399895-3785335, http://linkedlifedata.com/resource/pubmed/commentcorrection/9399895-6587361, http://linkedlifedata.com/resource/pubmed/commentcorrection/9399895-6847134, http://linkedlifedata.com/resource/pubmed/commentcorrection/9399895-6880604, http://linkedlifedata.com/resource/pubmed/commentcorrection/9399895-7196536, http://linkedlifedata.com/resource/pubmed/commentcorrection/9399895-7515903, http://linkedlifedata.com/resource/pubmed/commentcorrection/9399895-7523603, http://linkedlifedata.com/resource/pubmed/commentcorrection/9399895-7530769, http://linkedlifedata.com/resource/pubmed/commentcorrection/9399895-7545492, http://linkedlifedata.com/resource/pubmed/commentcorrection/9399895-7581446, http://linkedlifedata.com/resource/pubmed/commentcorrection/9399895-7675080, http://linkedlifedata.com/resource/pubmed/commentcorrection/9399895-7683738, http://linkedlifedata.com/resource/pubmed/commentcorrection/9399895-7887434, http://linkedlifedata.com/resource/pubmed/commentcorrection/9399895-8056435, http://linkedlifedata.com/resource/pubmed/commentcorrection/9399895-8081940, http://linkedlifedata.com/resource/pubmed/commentcorrection/9399895-8091227, http://linkedlifedata.com/resource/pubmed/commentcorrection/9399895-8163291, http://linkedlifedata.com/resource/pubmed/commentcorrection/9399895-8230163, http://linkedlifedata.com/resource/pubmed/commentcorrection/9399895-8317490, http://linkedlifedata.com/resource/pubmed/commentcorrection/9399895-8600387, http://linkedlifedata.com/resource/pubmed/commentcorrection/9399895-8651312, http://linkedlifedata.com/resource/pubmed/commentcorrection/9399895-8656905, http://linkedlifedata.com/resource/pubmed/commentcorrection/9399895-8696343, http://linkedlifedata.com/resource/pubmed/commentcorrection/9399895-8696345, http://linkedlifedata.com/resource/pubmed/commentcorrection/9399895-8696346
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0002-9297
pubmed:author
pubmed:issnType
Print
pubmed:volume
61
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1379-87
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
1997
pubmed:articleTitle
Genomewide scan of multiple sclerosis in Finnish multiplex families.
pubmed:affiliation
Department of Human Molecular Genetics, National Public Health Institute, Helsinki, Finland.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't