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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
2
|
pubmed:dateCreated |
1976-9-25
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pubmed:abstractText |
Seventeen children with clinical evidence of a recurrent brain tumor were treated with vincristine 1.5 mg/sq m weekly for 12 weeks with doses on alternate weeks thereafter. Eight of the 16 patients who received four or more doses of vincristine showed significant objective responses; these included patients with high-and low-grade astrocytomas and patients with medulloblastoma. Six of the eight who responded remained asymptomatic for more than 2 years. The toxicity encountered was minimal except for seizures possibly related to vincristine in three children, who were able to resume treatment. Vincristine therapy results in long-term regression in a wide variety of pediatric brain tumors and causes little or no toxicity.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
AIM
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pubmed:chemical | |
pubmed:status |
MEDLINE
|
pubmed:month |
Aug
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pubmed:issn |
0022-3085
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
45
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
135-40
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:939971-Astrocytoma,
pubmed-meshheading:939971-Brain Neoplasms,
pubmed-meshheading:939971-Child,
pubmed-meshheading:939971-Child, Preschool,
pubmed-meshheading:939971-Drug Evaluation,
pubmed-meshheading:939971-Female,
pubmed-meshheading:939971-Humans,
pubmed-meshheading:939971-Infant,
pubmed-meshheading:939971-Male,
pubmed-meshheading:939971-Medulloblastoma,
pubmed-meshheading:939971-Neoplasm Recurrence, Local,
pubmed-meshheading:939971-Seizures,
pubmed-meshheading:939971-Vincristine
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pubmed:year |
1976
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pubmed:articleTitle |
Response to vincristine of recurrent brain tumors in children.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Case Reports
|