Linked Life Data

939929

Source:http://linkedlifedata.com/resource/pubmed/id/939929

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1976-9-25
pubmed:abstractText
The effects of therapeutic concentrations of lidocaine, quinidine and phenytoin on the electrograms and excitability of ischemic canine myocardium were investigated. The threshold stimulation current was determined as the minimum current necessary to drive the ventricles at 300 msec intervals. Administration of the drugs did not change the threshold stimulation current of the control myocardium, but lidocaine (P less than 0.002), quinidine (P less than 0.01) and phenytoin (P less than 0.05) all markedly increased the threshold stimulation current of the ischemic tissue. The effects on the electrograms were small but consistent with current electrophysiological knowledge. This selective depression of the electrical activity of the ischemic tissue may form an important mechanism of action of these antiarrhythmic agents. However, this same effect may under certain conditions precipitate serious arrhythmias.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0022-0736
pubmed:author
pubmed:issnType
Print
pubmed:volume
9
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
203-9
pubmed:dateRevised
2009-11-11
pubmed:meshHeading
pubmed:year
1976
pubmed:articleTitle
Effects of lidocaine, phenytoin and quinidine on the ischemic canine myocardium.
pubmed:publicationType
Journal Article