| pubmed-article:9398625 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9398625 | lifeskim:mentions | umls-concept:C0042760 | lld:lifeskim |
| pubmed-article:9398625 | lifeskim:mentions | umls-concept:C0220847 | lld:lifeskim |
| pubmed-article:9398625 | lifeskim:mentions | umls-concept:C0003313 | lld:lifeskim |
| pubmed-article:9398625 | lifeskim:mentions | umls-concept:C0021024 | lld:lifeskim |
| pubmed-article:9398625 | lifeskim:mentions | umls-concept:C0439855 | lld:lifeskim |
| pubmed-article:9398625 | lifeskim:mentions | umls-concept:C1705241 | lld:lifeskim |
| pubmed-article:9398625 | lifeskim:mentions | umls-concept:C1705242 | lld:lifeskim |
| pubmed-article:9398625 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:9398625 | pubmed:dateCreated | 1998-1-13 | lld:pubmed |
| pubmed-article:9398625 | pubmed:abstractText | Antibody to the hypervariable region 1 of hepatitis C virus (HCV) is thought to have neutralizing activity. The complexity of hypervariable region 1 quasispecies was compared between immune complexed and non-immune complexed HCV particles. Immune complexes and non-immune complexes, including intact HCV virions, were separated by differential flotation centrifugation and immunoprecipitation, and immune complexes were observed in 9 of 11 patients with chronic hepatitis C. Considerable differences in both hypervariable region 1 quasispecies and predominant clones were demonstrated between immune complexes and non-immune complexes in 4 patients and not in 5 patients. These results suggest that the specificity of antibody to hypervariable region 1 is related to the formation of immune complexes and that escape mutants with highly different quasispecies are resistant to neutralization by antibody to hypervariable region 1. | lld:pubmed |
| pubmed-article:9398625 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9398625 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9398625 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:9398625 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9398625 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9398625 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9398625 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9398625 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:9398625 | pubmed:issn | 0006-291X | lld:pubmed |
| pubmed-article:9398625 | pubmed:author | pubmed-author:OkudaMM | lld:pubmed |
| pubmed-article:9398625 | pubmed:author | pubmed-author:OkazakiMM | lld:pubmed |
| pubmed-article:9398625 | pubmed:author | pubmed-author:OkitaKK | lld:pubmed |
| pubmed-article:9398625 | pubmed:author | pubmed-author:KorenagaMM | lld:pubmed |
| pubmed-article:9398625 | pubmed:author | pubmed-author:HinoKK | lld:pubmed |
| pubmed-article:9398625 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9398625 | pubmed:day | 26 | lld:pubmed |
| pubmed-article:9398625 | pubmed:volume | 240 | lld:pubmed |
| pubmed-article:9398625 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9398625 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9398625 | pubmed:pagination | 677-82 | lld:pubmed |
| pubmed-article:9398625 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:9398625 | pubmed:meshHeading | pubmed-meshheading:9398625-... | lld:pubmed |
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| pubmed-article:9398625 | pubmed:meshHeading | pubmed-meshheading:9398625-... | lld:pubmed |
| pubmed-article:9398625 | pubmed:meshHeading | pubmed-meshheading:9398625-... | lld:pubmed |
| pubmed-article:9398625 | pubmed:meshHeading | pubmed-meshheading:9398625-... | lld:pubmed |
| pubmed-article:9398625 | pubmed:meshHeading | pubmed-meshheading:9398625-... | lld:pubmed |
| pubmed-article:9398625 | pubmed:meshHeading | pubmed-meshheading:9398625-... | lld:pubmed |
| pubmed-article:9398625 | pubmed:meshHeading | pubmed-meshheading:9398625-... | lld:pubmed |
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| pubmed-article:9398625 | pubmed:meshHeading | pubmed-meshheading:9398625-... | lld:pubmed |
| pubmed-article:9398625 | pubmed:meshHeading | pubmed-meshheading:9398625-... | lld:pubmed |
| pubmed-article:9398625 | pubmed:meshHeading | pubmed-meshheading:9398625-... | lld:pubmed |
| pubmed-article:9398625 | pubmed:meshHeading | pubmed-meshheading:9398625-... | lld:pubmed |
| pubmed-article:9398625 | pubmed:meshHeading | pubmed-meshheading:9398625-... | lld:pubmed |
| pubmed-article:9398625 | pubmed:meshHeading | pubmed-meshheading:9398625-... | lld:pubmed |
| pubmed-article:9398625 | pubmed:meshHeading | pubmed-meshheading:9398625-... | lld:pubmed |
| pubmed-article:9398625 | pubmed:meshHeading | pubmed-meshheading:9398625-... | lld:pubmed |
| pubmed-article:9398625 | pubmed:meshHeading | pubmed-meshheading:9398625-... | lld:pubmed |
| pubmed-article:9398625 | pubmed:meshHeading | pubmed-meshheading:9398625-... | lld:pubmed |
| pubmed-article:9398625 | pubmed:year | 1997 | lld:pubmed |
| pubmed-article:9398625 | pubmed:articleTitle | Differences in hypervariable region 1 quasispecies between immune complexed and non-immune complexed hepatitis C virus particles. | lld:pubmed |
| pubmed-article:9398625 | pubmed:affiliation | First Department of Internal Medicine, Yamaguchi University, School of Medicine, Japan. | lld:pubmed |
| pubmed-article:9398625 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:9398625 | pubmed:publicationType | Comparative Study | lld:pubmed |
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| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9398625 | lld:pubmed |
