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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
3
|
| pubmed:dateCreated |
1998-1-13
|
| pubmed:abstractText |
Antibody to the hypervariable region 1 of hepatitis C virus (HCV) is thought to have neutralizing activity. The complexity of hypervariable region 1 quasispecies was compared between immune complexed and non-immune complexed HCV particles. Immune complexes and non-immune complexes, including intact HCV virions, were separated by differential flotation centrifugation and immunoprecipitation, and immune complexes were observed in 9 of 11 patients with chronic hepatitis C. Considerable differences in both hypervariable region 1 quasispecies and predominant clones were demonstrated between immune complexes and non-immune complexes in 4 patients and not in 5 patients. These results suggest that the specificity of antibody to hypervariable region 1 is related to the formation of immune complexes and that escape mutants with highly different quasispecies are resistant to neutralization by antibody to hypervariable region 1.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Nov
|
| pubmed:issn |
0006-291X
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
26
|
| pubmed:volume |
240
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
677-82
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:9398625-Adult,
pubmed-meshheading:9398625-Amino Acid Sequence,
pubmed-meshheading:9398625-Antibody Specificity,
pubmed-meshheading:9398625-Antigen-Antibody Complex,
pubmed-meshheading:9398625-Centrifugation, Density Gradient,
pubmed-meshheading:9398625-Cloning, Molecular,
pubmed-meshheading:9398625-Female,
pubmed-meshheading:9398625-Hepacivirus,
pubmed-meshheading:9398625-Hepatitis C,
pubmed-meshheading:9398625-Hepatitis C Antibodies,
pubmed-meshheading:9398625-Humans,
pubmed-meshheading:9398625-Immunoglobulin Variable Region,
pubmed-meshheading:9398625-Japan,
pubmed-meshheading:9398625-Male,
pubmed-meshheading:9398625-Middle Aged,
pubmed-meshheading:9398625-Molecular Sequence Data,
pubmed-meshheading:9398625-Polymerase Chain Reaction,
pubmed-meshheading:9398625-Precipitin Tests,
pubmed-meshheading:9398625-Sequence Analysis, DNA,
pubmed-meshheading:9398625-Sequence Homology, Amino Acid
|
| pubmed:year |
1997
|
| pubmed:articleTitle |
Differences in hypervariable region 1 quasispecies between immune complexed and non-immune complexed hepatitis C virus particles.
|
| pubmed:affiliation |
First Department of Internal Medicine, Yamaguchi University, School of Medicine, Japan.
|
| pubmed:publicationType |
Journal Article,
Comparative Study
|