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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
1998-1-7
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pubmed:abstractText |
Interleukin-1 beta (IL-1 beta) can induce dopaminergic axonal sprouting in the denervated striatum of parkinsonian animals. In order to determine whether IL-1 beta effects on dopaminergic axonal sprouting are mediated by the induction of astroglial-derived dopaminergic neurotrophic factors, effects of IL-1 beta treatment on acidic and basic fibroblast growth factor (aFGF and bFGF) and glial cell line-derived growth factor (GDNF) gene expression were examined in primary striatal astrocyte cultures and after in vivo administration. We found a selective induction of bFGF mRNA synthesis but not aFGF or GDNF mRNA after IL-1 beta treatment both in vitro and in vivo. This suggests that bFGF may be the putative endogenous dopaminergic neurotrophic factor mediating lesion-induced plasticity of dopamine neurons. In addition, to determine why recovery from injury becomes reduced with age, we examined whether there was an aging-associated decline in the ability of IL-1 beta to induce the synthesis of neurotrophic factors in middle-aged animals compared to young mice. Interestingly, IL-1 beta stimulated a greater induction in bFGF mRNA levels in the middle-aged mice compared to young mice. These results suggest that the regulation of bFGF and possibly its receptor signaling efficacy may vary as the brain ages.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/DNA, Complementary,
http://linkedlifedata.com/resource/pubmed/chemical/Fibroblast Growth Factor 1,
http://linkedlifedata.com/resource/pubmed/chemical/Fibroblast Growth Factor 2,
http://linkedlifedata.com/resource/pubmed/chemical/Gdnf protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Glial Cell Line-Derived...,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-1,
http://linkedlifedata.com/resource/pubmed/chemical/Nerve Growth Factors,
http://linkedlifedata.com/resource/pubmed/chemical/Nerve Tissue Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0014-4886
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
148
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
348-59
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:9398477-Age Factors,
pubmed-meshheading:9398477-Aging,
pubmed-meshheading:9398477-Animals,
pubmed-meshheading:9398477-Astrocytes,
pubmed-meshheading:9398477-Cells, Cultured,
pubmed-meshheading:9398477-Corpus Striatum,
pubmed-meshheading:9398477-DNA, Complementary,
pubmed-meshheading:9398477-Dopamine,
pubmed-meshheading:9398477-Fibroblast Growth Factor 1,
pubmed-meshheading:9398477-Fibroblast Growth Factor 2,
pubmed-meshheading:9398477-Gene Expression Regulation,
pubmed-meshheading:9398477-Glial Cell Line-Derived Neurotrophic Factor,
pubmed-meshheading:9398477-Interleukin-1,
pubmed-meshheading:9398477-Male,
pubmed-meshheading:9398477-Mice,
pubmed-meshheading:9398477-Mice, Inbred C57BL,
pubmed-meshheading:9398477-Nerve Growth Factors,
pubmed-meshheading:9398477-Nerve Tissue Proteins,
pubmed-meshheading:9398477-Neuronal Plasticity,
pubmed-meshheading:9398477-Parkinson Disease,
pubmed-meshheading:9398477-RNA, Messenger
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pubmed:year |
1997
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pubmed:articleTitle |
Regulation of astroglial-derived dopaminergic neurotrophic factors by interleukin-1 beta in the striatum of young and middle-aged mice.
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pubmed:affiliation |
Fishberg Research Center for Neurobiology, Mount Sinai School of Medicine, New York, New York 10029, USA.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, U.S. Gov't, P.H.S.
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