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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5345
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pubmed:dateCreated |
1997-12-24
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pubmed:databankReference |
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pubmed:abstractText |
Dorsoventral patterning of vertebrate and Drosophila embryos requires bone morphogenetic proteins (BMPs) and antagonists of BMP activity. The Drosophila gene tolloid encodes a metalloprotease similar to BMP-1 that interacts genetically with decapentaplegic, the Drosophila homolog of vertebrate BMP-2/4. Zebrafish embryos overexpressing a zebrafish homolog of tolloid were shown to resemble loss-of-function mutations in chordino, the zebrafish homolog of the Xenopus BMP-4 antagonist Chordin. Furthermore, Chordin was degraded by COS cells expressing Tolloid. These data suggest that Tolloid antagonizes Chordin activity by proteolytically cleaving Chordin. A conserved function for zebrafish and Drosophila Tolloid during embryogenesis is proposed.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Bone Morphogenetic Protein 4,
http://linkedlifedata.com/resource/pubmed/chemical/Bone Morphogenetic Protein Receptors,
http://linkedlifedata.com/resource/pubmed/chemical/Bone Morphogenetic Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Drosophila Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Glycoproteins,
http://linkedlifedata.com/resource/pubmed/chemical/Insect Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Intercellular Signaling Peptides...,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Cell Surface,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Growth Factor,
http://linkedlifedata.com/resource/pubmed/chemical/Tolloid-Like Metalloproteinases,
http://linkedlifedata.com/resource/pubmed/chemical/Xenopus Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Zebrafish Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/bmp4 protein, Xenopus,
http://linkedlifedata.com/resource/pubmed/chemical/bmp4 protein, zebrafish,
http://linkedlifedata.com/resource/pubmed/chemical/chordin,
http://linkedlifedata.com/resource/pubmed/chemical/tolloid protein, Drosophila
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0036-8075
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
12
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pubmed:volume |
278
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1937-40
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:9395394-Animals,
pubmed-meshheading:9395394-Body Patterning,
pubmed-meshheading:9395394-Bone Morphogenetic Protein 4,
pubmed-meshheading:9395394-Bone Morphogenetic Protein Receptors,
pubmed-meshheading:9395394-Bone Morphogenetic Proteins,
pubmed-meshheading:9395394-COS Cells,
pubmed-meshheading:9395394-Cell Lineage,
pubmed-meshheading:9395394-Drosophila Proteins,
pubmed-meshheading:9395394-Embryo, Nonmammalian,
pubmed-meshheading:9395394-Gene Expression Regulation, Developmental,
pubmed-meshheading:9395394-Glycoproteins,
pubmed-meshheading:9395394-Insect Proteins,
pubmed-meshheading:9395394-Intercellular Signaling Peptides and Proteins,
pubmed-meshheading:9395394-RNA, Messenger,
pubmed-meshheading:9395394-Receptors, Cell Surface,
pubmed-meshheading:9395394-Receptors, Growth Factor,
pubmed-meshheading:9395394-Signal Transduction,
pubmed-meshheading:9395394-Tolloid-Like Metalloproteinases,
pubmed-meshheading:9395394-Transfection,
pubmed-meshheading:9395394-Xenopus Proteins,
pubmed-meshheading:9395394-Zebrafish,
pubmed-meshheading:9395394-Zebrafish Proteins
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pubmed:year |
1997
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pubmed:articleTitle |
Cleavage of the BMP-4 antagonist chordin by zebrafish tolloid.
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pubmed:affiliation |
Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC), CNRS/INSERM/ULP, BP 163, 67404 Illkirch Cedex, C.U. de Strasbourg, France.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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