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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
21
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pubmed:dateCreated |
1998-1-2
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pubmed:abstractText |
Isoprenaline-induced desensitization in vitro in rat trachea was studied in the presence of the Ca2+-channel blockers (Ca2+-CBs) verapamil and nitrendipine. The concentration-response curves for isoprenaline were determined in a noncumulative manner using carbachol as contracting agent, and then desensitization was achieved by 40-min incubation of the tracheal preparations with isoprenaline (1 microM). The effect of verapamil and nitrendipine was studied by the addition of each Ca2+-CB to the desensitizing solution. Both verapamil and nitrendipine reduced the isoprenaline-induced desensitization in the rat trachea.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
0024-3205
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
61
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
PL 315-20
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:9395258-Animals,
pubmed-meshheading:9395258-Calcium Channel Blockers,
pubmed-meshheading:9395258-Carbachol,
pubmed-meshheading:9395258-Isoproterenol,
pubmed-meshheading:9395258-Male,
pubmed-meshheading:9395258-Muscle Contraction,
pubmed-meshheading:9395258-Muscle Relaxation,
pubmed-meshheading:9395258-Nitrendipine,
pubmed-meshheading:9395258-Rats,
pubmed-meshheading:9395258-Rats, Wistar,
pubmed-meshheading:9395258-Trachea,
pubmed-meshheading:9395258-Verapamil
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pubmed:year |
1997
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pubmed:articleTitle |
Effect of Ca2+-channel blockers on isoprenaline-induced desensitization in rat trachea.
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pubmed:affiliation |
Institute of Physiology, Bulgarian Academy of Sciences, Sofia.
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pubmed:publicationType |
Journal Article,
In Vitro,
Research Support, Non-U.S. Gov't
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