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rdf:type |
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lifeskim:mentions |
umls-concept:C0009015,
umls-concept:C0017262,
umls-concept:C0086418,
umls-concept:C0185117,
umls-concept:C0205314,
umls-concept:C0288912,
umls-concept:C0449774,
umls-concept:C0679622,
umls-concept:C0936012,
umls-concept:C1335532,
umls-concept:C1711351,
umls-concept:C2911684
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pubmed:issue |
1
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|
pubmed:dateCreated |
1998-1-7
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pubmed:databankReference |
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pubmed:abstractText |
The import of many proteins into the nucleus is mediated by the importin-alpha/beta heterodimer. While only one importin-beta gene has been found, several forms of importin-alpha have been described. In addition to the three human importin-alphas already identified, we report here the primary structure of two new human importin-alpha proteins. The five known human importin-alpha subunits can be classified into three subfamilies that appear conserved in higher eukaryotic organisms. We show by immunoblotting that the different importin-alpha subfamilies are expressed in a variety of human tissues and mammalian cell lines.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0014-5793
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
3
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pubmed:volume |
417
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
104-8
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pubmed:dateRevised |
2004-11-17
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pubmed:meshHeading |
pubmed-meshheading:9395085-Amino Acid Sequence,
pubmed-meshheading:9395085-Animals,
pubmed-meshheading:9395085-Base Sequence,
pubmed-meshheading:9395085-Cloning, Molecular,
pubmed-meshheading:9395085-DNA, Complementary,
pubmed-meshheading:9395085-Gene Expression,
pubmed-meshheading:9395085-HeLa Cells,
pubmed-meshheading:9395085-Humans,
pubmed-meshheading:9395085-Immunoblotting,
pubmed-meshheading:9395085-Jurkat Cells,
pubmed-meshheading:9395085-Karyopherins,
pubmed-meshheading:9395085-Molecular Sequence Data,
pubmed-meshheading:9395085-Nuclear Proteins,
pubmed-meshheading:9395085-RNA, Messenger,
pubmed-meshheading:9395085-Rabbits,
pubmed-meshheading:9395085-Sequence Homology, Amino Acid,
pubmed-meshheading:9395085-Tissue Distribution,
pubmed-meshheading:9395085-Tumor Cells, Cultured
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pubmed:year |
1997
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pubmed:articleTitle |
Cloning of two novel human importin-alpha subunits and analysis of the expression pattern of the importin-alpha protein family.
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pubmed:affiliation |
Franz Volhard Clinic, Humboldt University of Berlin, Germany.
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pubmed:publicationType |
Journal Article
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