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rdf:type |
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lifeskim:mentions |
umls-concept:C0003320,
umls-concept:C0006033,
umls-concept:C0006035,
umls-concept:C0021758,
umls-concept:C0024198,
umls-concept:C0025252,
umls-concept:C0036536,
umls-concept:C0036537,
umls-concept:C0037973,
umls-concept:C0079189,
umls-concept:C0205101,
umls-concept:C0205369,
umls-concept:C0871261,
umls-concept:C0927232,
umls-concept:C1704632,
umls-concept:C1706817,
umls-concept:C2911692
|
|
pubmed:issue |
2
|
|
pubmed:dateCreated |
1997-12-23
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|
pubmed:abstractText |
The neurological manifestations of Lyme disease have been proposed to be partly due to cytokine-mediated immunopathological mechanisms. In this study, the number of Borrelia-specific cells secreting interferon-gamma and interleukin-4 was determined in blood and cerebrospinal fluid from patients with CNS borreliosis (n = 23), other neurological diseases (n = 20), and in blood from healthy controls (n = 10), utilizing an ELISPOT-assay. Elevated specific secretion of IFN-gamma was found in CNS borreliosis, most pronounced in cerebrospinal fluid, whereas secretion of IL-4 was strikingly low. This may indicate that symptoms are due to side effects of the immune response, since IFN-gamma secretion in the absence of corresponding levels of IL-4 may be associated with tissue destruction.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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|
pubmed:citationSubset |
IM
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|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
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pubmed:month |
Nov
|
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pubmed:issn |
0165-5728
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pubmed:author |
|
|
pubmed:issnType |
Print
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pubmed:volume |
79
|
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pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
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pubmed:pagination |
155-62
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:9394788-Adult,
pubmed-meshheading:9394788-Aged,
pubmed-meshheading:9394788-Aged, 80 and over,
pubmed-meshheading:9394788-Bacterial Proteins,
pubmed-meshheading:9394788-Borrelia,
pubmed-meshheading:9394788-Borrelia Infections,
pubmed-meshheading:9394788-Central Nervous System,
pubmed-meshheading:9394788-Central Nervous System Diseases,
pubmed-meshheading:9394788-Child,
pubmed-meshheading:9394788-Cytokines,
pubmed-meshheading:9394788-Epitopes,
pubmed-meshheading:9394788-Female,
pubmed-meshheading:9394788-Humans,
pubmed-meshheading:9394788-Interferon-gamma,
pubmed-meshheading:9394788-Interleukin-4,
pubmed-meshheading:9394788-Lyme Disease,
pubmed-meshheading:9394788-Male,
pubmed-meshheading:9394788-Middle Aged,
pubmed-meshheading:9394788-Spirochaetales
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|
pubmed:year |
1997
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|
pubmed:articleTitle |
Compartmentalization of antigen specific cytokine responses to the central nervous system in CNS borreliosis: secretion of IFN-gamma predominates over IL-4 secretion in response to outer surface proteins of Lyme disease Borrelia spirochetes.
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pubmed:affiliation |
Department of Neurology, Faculty of Health Sciences, University Hospital, Linköping, Sweden.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
|
