Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1-2
pubmed:dateCreated
1997-12-29
pubmed:abstractText
Activation of microglia is associated with neural damage and may aid repair of the CNS. To begin to investigate their role, microglia purified from mouse brain were grown in media conditioned (CM) by goldfish optic nerve (GFON), optic tectum (GFOT), vagal lobe, telencephalon and cerebellum, and medium conditioned by rat optic nerves (RON). Microglia maintained in GFON- or GFOT-CM assumed an ameboid morphology, whereas microglia grown in media conditioned by the other neural tissues produced long, crenellated processes that resembled the ramified microglial form. Microglia maintained in all types of CM functioned as antigen presenting cells in a MHC-restricted manner when tested on conalbumin-specific Thelper (Th) cells, except for microglia maintained in GFON- and GFOT-CM. These studies suggest that GFON, in contrast to RON, produces a substance(s) that affects microglial morphology and immune reactivity, and may promote the vigorous regeneration seen in GFON after damage.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
0020-7454
pubmed:author
pubmed:issnType
Print
pubmed:volume
91
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
133-46
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1997
pubmed:articleTitle
Modulation of microglial form and immune function by factors released from goldfish optic nerves.
pubmed:affiliation
Neuroscience Research Laboratories, Florida Atlantic University, Boca Raton 33431, USA. Perry@walt.ccs.fau.edu
pubmed:publicationType
Journal Article, Comparative Study, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't