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pubmed-article:9393338pubmed:abstractTextInflammatory and coagulation processes are both affected in meningococcaemia. Severe acquired protein-C deficiency in meningococcaemia is usually associated with substantial mortality: in survivors, skin grafts, amputation, and end-organ failure are not uncommon. Protein C is a natural anticoagulant and also has important anti-inflammatory activity. We assessed the effects of early replacement therapy with protein-C concentrate together with continuous veno-venous haemodiafiltration and conventional treatment in meningococcaemia.lld:pubmed
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pubmed-article:9393338pubmed:articleTitleUse of protein-C concentrate, heparin, and haemodiafiltration in meningococcus-induced purpura fulminans.lld:pubmed
pubmed-article:9393338pubmed:affiliationDepartment of Paediatric Haematology, National Children's Hospital, Dublin, Ireland.lld:pubmed
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