Linked Life Data

9389678

Source:http://linkedlifedata.com/resource/pubmed/id/9389678

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1998-1-27
pubmed:abstractText
Two extracts of St. John s Wort were compared with respect to their action on in vivo monitored field potentials from four brain areas of the freely moving rat. Quantitative assessment of the drug action revealed a late onset (3 to 4 hours after oral application) and main effects on the frontal cortex. Changes consisted in electrical power alterations reminiscent of the action of antidepressive and/or analgesic drugs. Particular frequency bands affected first line were alpha1 and alpha2, which in some way are related to serotonergic and dopaminergic transmission. From this it is concluded that St. Johns Wort could be used for the indication of depression with predictable success. The extract labeled "K" turned out to be superior especially after repetitive application and could thus far be used for further studies.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0949-2321
pubmed:author
pubmed:issnType
Print
pubmed:day
18
pubmed:volume
1
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
157-67
pubmed:dateRevised
2003-11-14
pubmed:meshHeading
pubmed:year
1995
pubmed:articleTitle
Pharmacodynamic effects of St. John's Wort on rat intracerebral field potentials.
pubmed:affiliation
Pro Science Private Research Institute GmbH, Linden, Germany.
pubmed:publicationType
Journal Article