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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5-6
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pubmed:dateCreated |
1998-1-27
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pubmed:abstractText |
The purpose of this paper is to report the clinical characteristics and treatment outcome following different therapeutic approaches in a large series of patients with primary low-grade MALT lymphoma of the stomach. A total of ninety-three patients (median age 63 years) were reviewed. The patients were treated by different modalities (local treatment alone, combined treatment, chemotherapy, antibiotics alone); seven patients refused any treatment. The antibiotic-treated group of patients was prospectively followed with regular endoscopic biopsies, and their responses were histologically evaluated. The 5-years projected overall survival is 82% (95% C.I.; 67%-91%) in the series as a whole. Second tumors were observed in 21.5% of the patients in this series (95% CI 14%v to 31%). There was no apparent difference in overall survival and event-free survival between patients who received different treatments. In the antibiotic-treated group histologic regression of MALT lymphoma was documented in 67% of patients (95% CI 51% to 80%). In conclusion the indolent nature of the disease justifies a conservative approach. The use of antibiotics as first-line therapy may avert or at least postpone the indication for surgical resection in the majority of patients.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
1042-8194
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pubmed:author |
pubmed-author:BertoniFF,
pubmed-author:CapellaCC,
pubmed-author:CavalliFF,
pubmed-author:MorandiEE,
pubmed-author:PascarellaAA,
pubmed-author:PedrinisEE,
pubmed-author:PinottiGG,
pubmed-author:RoggeroEE,
pubmed-author:SalettiPP,
pubmed-author:SantandreaGG,
pubmed-author:Sava?II,
pubmed-author:SavioEE,
pubmed-author:ZuccaEE
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pubmed:issnType |
Print
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pubmed:volume |
26
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
527-37
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pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:9389360-Adult,
pubmed-meshheading:9389360-Aged,
pubmed-meshheading:9389360-Aged, 80 and over,
pubmed-meshheading:9389360-Anti-Bacterial Agents,
pubmed-meshheading:9389360-Antineoplastic Agents, Alkylating,
pubmed-meshheading:9389360-Antineoplastic Combined Chemotherapy Protocols,
pubmed-meshheading:9389360-Chlorambucil,
pubmed-meshheading:9389360-Combined Modality Therapy,
pubmed-meshheading:9389360-Cyclophosphamide,
pubmed-meshheading:9389360-Doxorubicin,
pubmed-meshheading:9389360-Female,
pubmed-meshheading:9389360-Helicobacter Infections,
pubmed-meshheading:9389360-Helicobacter pylori,
pubmed-meshheading:9389360-Humans,
pubmed-meshheading:9389360-Lymphoma, B-Cell, Marginal Zone,
pubmed-meshheading:9389360-Lymphoma, Non-Hodgkin,
pubmed-meshheading:9389360-Male,
pubmed-meshheading:9389360-Middle Aged,
pubmed-meshheading:9389360-Prednisone,
pubmed-meshheading:9389360-Prognosis,
pubmed-meshheading:9389360-Stomach Neoplasms,
pubmed-meshheading:9389360-Treatment Outcome,
pubmed-meshheading:9389360-Vincristine
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pubmed:year |
1997
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pubmed:articleTitle |
Clinical features, treatment and outcome in a series of 93 patients with low-grade gastric MALT lymphoma.
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pubmed:affiliation |
Divisione Clinica Medica, Ospedale Multizonale, Varese, Italy.
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pubmed:publicationType |
Journal Article,
Clinical Trial,
Research Support, Non-U.S. Gov't
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