Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
11
|
| pubmed:dateCreated |
1997-12-11
|
| pubmed:abstractText |
Immunohistochemistry using monoclonal antibodies against human inhibin, a peptide hormone produced by ovarian granulosa cells to inhibit follicle-stimulating hormone (FSH), has been recently applied to diagnostic anatomic pathology. This investigation hypothesizes that inhibin immunohistochemistry will aid in the crucial clinical distinction between sex cord-stromal and other primary ovarian neoplasms. Available H&E slides and clinical information from a retrospective surgical series of 186 primary ovarian tumors were reviewed to verify diagnoses, and representative paraffin sections were immunostained with anti-inhibin (R1 monoclonal, Serotec, Kidlington, Oxford, UK). Immunoreactivity was graded as weak/strong (W/S), and the proportion of strong staining cells was coded as follows: S1 = <10%, S2 = 10%-50%, S3 = >50%, respectively. Inhibin immunoreactivity for 137 sex cord-stromal lesions was as follows: 100% of 66 granulosa cell tumors: 80% S3, 20% S2; 100% of 17 Sertoli-stromal tumors: 90% S3, 10% S2; 100% of 13 hyperplastic follicular/stromal lesions: 90% S3, 10% S2; 100% of six steroid cell tumors: 100% S3; 90% of 18 thecomas: 40% S3, 10% S2, 10% S1, 30% W; 0% of 12 fibromas, three myxomas, and two sclerosing stromal tumors. None (0 of 49) of the other ovarian neoplasms exhibited inhibin: 22 carcinomas, 12 carcinosarcomas, seven small cell carcinomas, six germ cell tumors, and two lymphomas. In the typical case, the distinction between sex cord-stromal and other ovarian neoplasms requires nothing more than routine pathological examination. In diagnostically challenging cases, our data indicate that inhibin immunohistochemistry is a very useful adjunct because granulosa and sertoli-stromal tumors are positive whereas other potential mimickers have been negative thus far.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Nov
|
| pubmed:issn |
0046-8177
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
28
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
1247-54
|
| pubmed:dateRevised |
2008-11-21
|
| pubmed:meshHeading |
pubmed-meshheading:9385929-Adolescent,
pubmed-meshheading:9385929-Adult,
pubmed-meshheading:9385929-Aged,
pubmed-meshheading:9385929-Aged, 80 and over,
pubmed-meshheading:9385929-Antibodies, Monoclonal,
pubmed-meshheading:9385929-Child,
pubmed-meshheading:9385929-Child, Preschool,
pubmed-meshheading:9385929-Female,
pubmed-meshheading:9385929-Granulosa Cell Tumor,
pubmed-meshheading:9385929-Humans,
pubmed-meshheading:9385929-Immunohistochemistry,
pubmed-meshheading:9385929-Infant,
pubmed-meshheading:9385929-Inhibins,
pubmed-meshheading:9385929-Middle Aged,
pubmed-meshheading:9385929-Mucin-1,
pubmed-meshheading:9385929-Neoplasms, Gonadal Tissue,
pubmed-meshheading:9385929-Ovarian Neoplasms,
pubmed-meshheading:9385929-Sertoli Cell Tumor,
pubmed-meshheading:9385929-Sertoli-Leydig Cell Tumor,
pubmed-meshheading:9385929-Sex Cord-Gonadal Stromal Tumors
|
| pubmed:year |
1997
|
| pubmed:articleTitle |
Inhibin immunohistochemistry applied to ovarian neoplasms: a novel, effective, diagnostic tool.
|
| pubmed:affiliation |
University of California-Davis Medical Center, Sacramento 95817, USA.
|
| pubmed:publicationType |
Journal Article
|