| pubmed-article:9385375 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9385375 | lifeskim:mentions | umls-concept:C0431085 | lld:lifeskim |
| pubmed-article:9385375 | lifeskim:mentions | umls-concept:C0017337 | lld:lifeskim |
| pubmed-article:9385375 | lifeskim:mentions | umls-concept:C0441655 | lld:lifeskim |
| pubmed-article:9385375 | lifeskim:mentions | umls-concept:C0040649 | lld:lifeskim |
| pubmed-article:9385375 | lifeskim:mentions | umls-concept:C0162789 | lld:lifeskim |
| pubmed-article:9385375 | lifeskim:mentions | umls-concept:C0936012 | lld:lifeskim |
| pubmed-article:9385375 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:9385375 | pubmed:dateCreated | 1997-12-24 | lld:pubmed |
| pubmed-article:9385375 | pubmed:abstractText | In this paper we present a new application of the detection of nuclear transcripts by fluorescence in situ hybridization (FISH) for studying the transcriptional activity of amplified genes in tumour cells. As a model, we have used the A431 cell line in which several amplification sites have been identified. We focused on two amplified regions: (1) the 6p12 region, which was found amplified by using comparative genomic hybridization, and which contains an amplification of the hsp90 beta gene; (2) the 7p12-p13 region, which displays a 20- to 30-fold amplification of the gene encoding the epidermal growth factor receptor (EGFr). By using FISH to detect nuclear transcripts, we show that the extra-copies of the hsp90 beta and EGFr genes are actively transcribed within the sites of amplification. This work illustrates the potential of this method as a tool for functional in situ cytogenetic analyses. | lld:pubmed |
| pubmed-article:9385375 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9385375 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9385375 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:9385375 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9385375 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9385375 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9385375 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9385375 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:9385375 | pubmed:issn | 0340-6717 | lld:pubmed |
| pubmed-article:9385375 | pubmed:author | pubmed-author:RocchiMM | lld:pubmed |
| pubmed-article:9385375 | pubmed:author | pubmed-author:JollyCC | lld:pubmed |
| pubmed-article:9385375 | pubmed:author | pubmed-author:Robert-Nicoud... | lld:pubmed |
| pubmed-article:9385375 | pubmed:author | pubmed-author:Vourc'hCC | lld:pubmed |
| pubmed-article:9385375 | pubmed:author | pubmed-author:MichellandSS | lld:pubmed |
| pubmed-article:9385375 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9385375 | pubmed:volume | 101 | lld:pubmed |
| pubmed-article:9385375 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9385375 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9385375 | pubmed:pagination | 81-7 | lld:pubmed |
| pubmed-article:9385375 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
| pubmed-article:9385375 | pubmed:meshHeading | pubmed-meshheading:9385375-... | lld:pubmed |
| pubmed-article:9385375 | pubmed:meshHeading | pubmed-meshheading:9385375-... | lld:pubmed |
| pubmed-article:9385375 | pubmed:meshHeading | pubmed-meshheading:9385375-... | lld:pubmed |
| pubmed-article:9385375 | pubmed:meshHeading | pubmed-meshheading:9385375-... | lld:pubmed |
| pubmed-article:9385375 | pubmed:meshHeading | pubmed-meshheading:9385375-... | lld:pubmed |
| pubmed-article:9385375 | pubmed:meshHeading | pubmed-meshheading:9385375-... | lld:pubmed |
| pubmed-article:9385375 | pubmed:meshHeading | pubmed-meshheading:9385375-... | lld:pubmed |
| pubmed-article:9385375 | pubmed:meshHeading | pubmed-meshheading:9385375-... | lld:pubmed |
| pubmed-article:9385375 | pubmed:meshHeading | pubmed-meshheading:9385375-... | lld:pubmed |
| pubmed-article:9385375 | pubmed:meshHeading | pubmed-meshheading:9385375-... | lld:pubmed |
| pubmed-article:9385375 | pubmed:meshHeading | pubmed-meshheading:9385375-... | lld:pubmed |
| pubmed-article:9385375 | pubmed:meshHeading | pubmed-meshheading:9385375-... | lld:pubmed |
| pubmed-article:9385375 | pubmed:meshHeading | pubmed-meshheading:9385375-... | lld:pubmed |
| pubmed-article:9385375 | pubmed:year | 1997 | lld:pubmed |
| pubmed-article:9385375 | pubmed:articleTitle | Analysis of the transcriptional activity of amplified genes in tumour cells by fluorescence in situ hybridization. | lld:pubmed |
| pubmed-article:9385375 | pubmed:affiliation | Inserm U309, Equipe DyOGen, Institut Albert Bonniot, Université Joseph Fourier Grenoble I, La Tronche, France. caroline.jolly@ujf-grenoble.fr | lld:pubmed |
| pubmed-article:9385375 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:9385375 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9385375 | lld:pubmed |
