Linked Life Data

9385121

Source:http://linkedlifedata.com/resource/pubmed/id/9385121

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
11
pubmed:dateCreated
1998-2-20
pubmed:abstractText
The central action of a plant extract containing hyperici herba flore extractum siccum has been investigated in freely moving rats during a 6 h exposure with two dosages. After frequency analysis of local field potentials electrical power changes of delta waves and alpha2 waves (less pronounced) could be observed within the frontal cortex and hippocampus. As these frequencies are changed predominantly in the presence of drugs acting at the cholinergic or dopaminergic transmitter system, a similar mode of action can be suspected for this plant extract. Despite the fact that statistical significance could only be observed during the fourth hour (p <0.1), the changes induced by the higher dose of the extract containing 1 mg of hypericine were very stable from the 2. to 4. hour after oral application. Classification of the parameters obtained by means of discriminant analysis revealed a trend into the direction of antidepressive EEG drug profiles. Results suggest that quantitative EEG analysis is a very sensitive methodology for the description of pharmacodynamic actions of plant extracts and data can be compared to the action of pure chemical entities.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
0949-2321
pubmed:author
pubmed:issnType
Print
pubmed:day
28
pubmed:volume
2
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
491-6
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1997
pubmed:articleTitle
Central action of hyperici herba cum flore extractum siccum in freely moving rats.
pubmed:affiliation
Pro Science Private Research Clinic GmbH -med. Forschung und Entwicklung-, Kurt-Schumacher-Str. 9, Linden D-35440, Germany.
pubmed:publicationType
Journal Article, Comparative Study