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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
11
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pubmed:dateCreated |
1998-1-27
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pubmed:abstractText |
The problem of how macromolecules adopt specific shapes to recognize small molecules in their environment is readily addressed through in vitro selections (the SELEX protocol). RNA-antibiotic interactions are particularly attractive systems for study because they provide an opportunity to expand our understanding of molecular recognition by RNA and to facilitate ribosomal modeling. Specifically, the antibiotic chloramphenicol (Cam) naturally binds bacterial ribosomes in the 'peptidyl transferase loop' of 23S ribosomal RNA to inhibit peptide bond formation.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
1074-5521
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
4
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
833-43
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:9384530-Base Sequence,
pubmed-meshheading:9384530-Chloramphenicol,
pubmed-meshheading:9384530-Enzyme Inhibitors,
pubmed-meshheading:9384530-Kinetics,
pubmed-meshheading:9384530-Magnetic Resonance Spectroscopy,
pubmed-meshheading:9384530-Molecular Sequence Data,
pubmed-meshheading:9384530-Nucleic Acid Conformation,
pubmed-meshheading:9384530-Peptidyl Transferases,
pubmed-meshheading:9384530-RNA,
pubmed-meshheading:9384530-RNA, Ribosomal, 23S
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pubmed:year |
1997
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pubmed:articleTitle |
RNA aptamers to the peptidyl transferase inhibitor chloramphenicol.
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pubmed:affiliation |
Department of Molecular, Cellular and Development Biology, University of Colorado, Boulder, CO 80309-0347, USA. dhburke@beagle.colorado.edu
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, U.S. Gov't, Non-P.H.S.,
Research Support, Non-U.S. Gov't
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