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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
11
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pubmed:dateCreated |
1998-1-15
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pubmed:abstractText |
We describe a new approach to drug discovery which joins the technologies of medicinal and combinatorial chemistry, allowing selection of the most active variant of a lead compound from a large (> 10(12)) pool. A small-molecule covalent inhibitor of elastase was coupled to a randomized pool of RNA, and this assembly was iteratively selected for oligonucleotide sequences that promote the covalent reaction of the inhibitor with the human neutrophil elastase (hNE) active site.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/CTSG protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Cathepsin G,
http://linkedlifedata.com/resource/pubmed/chemical/Cathepsins,
http://linkedlifedata.com/resource/pubmed/chemical/Ctsg protein, rat,
http://linkedlifedata.com/resource/pubmed/chemical/Leukocyte Elastase,
http://linkedlifedata.com/resource/pubmed/chemical/Oligonucleotides,
http://linkedlifedata.com/resource/pubmed/chemical/RNA,
http://linkedlifedata.com/resource/pubmed/chemical/Serine Endopeptidases,
http://linkedlifedata.com/resource/pubmed/chemical/Serine Proteinase Inhibitors
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
1074-5521
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
2
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
741-50
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:9383481-Animals,
pubmed-meshheading:9383481-Base Sequence,
pubmed-meshheading:9383481-Cathepsin G,
pubmed-meshheading:9383481-Cathepsins,
pubmed-meshheading:9383481-Chemistry, Physical,
pubmed-meshheading:9383481-Cross Reactions,
pubmed-meshheading:9383481-Humans,
pubmed-meshheading:9383481-Leukocyte Elastase,
pubmed-meshheading:9383481-Molecular Sequence Data,
pubmed-meshheading:9383481-Neutrophils,
pubmed-meshheading:9383481-Oligonucleotides,
pubmed-meshheading:9383481-Organ Size,
pubmed-meshheading:9383481-Physicochemical Phenomena,
pubmed-meshheading:9383481-Polymerase Chain Reaction,
pubmed-meshheading:9383481-RNA,
pubmed-meshheading:9383481-Rats,
pubmed-meshheading:9383481-Respiratory Distress Syndrome, Adult,
pubmed-meshheading:9383481-Serine Endopeptidases,
pubmed-meshheading:9383481-Serine Proteinase Inhibitors,
pubmed-meshheading:9383481-Substrate Specificity
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pubmed:year |
1995
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pubmed:articleTitle |
In vitro selection of RNA-based irreversible inhibitors of human neutrophil elastase.
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pubmed:affiliation |
NeXstar Pharmaceuticals, Inc., Boulder, CO 80301, USA.
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pubmed:publicationType |
Journal Article
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