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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
8
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pubmed:dateCreated |
1998-1-15
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pubmed:abstractText |
Brevetoxins are polyether ladder toxins that are ichthyotoxic at nanomolar concentrations. They bind to voltage-gated sodium channels, causing four distinct electrophysiological effects: (i) a shift of activation potential; (ii) occurrence of subconductance states; (iii) induction of longer mean open times of the channel; and (iv) inhibition of channel inactivation. We set out to determine whether these functions all require the same structural elements within the brevetoxin molecules.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
1074-5521
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
2
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
533-41
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:9383457-Animals,
pubmed-meshheading:9383457-Electrophysiology,
pubmed-meshheading:9383457-Male,
pubmed-meshheading:9383457-Marine Toxins,
pubmed-meshheading:9383457-Membrane Potentials,
pubmed-meshheading:9383457-Models, Molecular,
pubmed-meshheading:9383457-Neurons,
pubmed-meshheading:9383457-Neurotoxins,
pubmed-meshheading:9383457-Nodose Ganglion,
pubmed-meshheading:9383457-Oxocins,
pubmed-meshheading:9383457-Patch-Clamp Techniques,
pubmed-meshheading:9383457-Rats,
pubmed-meshheading:9383457-Rats, Sprague-Dawley,
pubmed-meshheading:9383457-Sodium Channel Blockers,
pubmed-meshheading:9383457-Sodium Channels,
pubmed-meshheading:9383457-Structure-Activity Relationship,
pubmed-meshheading:9383457-Synaptosomes
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pubmed:year |
1995
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pubmed:articleTitle |
The relationship of brevetoxin 'length' and A-ring functionality to binding and activity in neuronal sodium channels.
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pubmed:affiliation |
Department of Chemistry, University of Miami, Coral Gables, FL 33124, USA.
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pubmed:publicationType |
Journal Article,
In Vitro,
Research Support, U.S. Gov't, P.H.S.
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