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rdf:type |
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lifeskim:mentions |
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pubmed:dateCreated |
1998-1-7
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pubmed:abstractText |
Mice homozygous for the vitiligo mutation of the microphthalmia (Mitf) gene have a retinal degeneration characterized by slow loss of photoreceptor cells and compromised retinal pigment epithelial (RPE) structure and function. The levels of retinyl esters, which are essential for generation of 11-cis-retinaldehyde for the formation of rhodopsin, were reported previously to be elevated by 6 weeks postnatally in the RPE of vitiligo mutant mice. The purpose of the present study was to determine whether this elevation was due to increased activity of lecithin:retinol acyl transferase (LRAT) the enzyme that converts all-trans-retinol to retinyl esters.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
1090-0535
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:day |
24
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pubmed:volume |
3
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
11
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:9383334-Acyltransferases,
pubmed-meshheading:9383334-Aging,
pubmed-meshheading:9383334-Animals,
pubmed-meshheading:9383334-Chromatography, High Pressure Liquid,
pubmed-meshheading:9383334-DNA-Binding Proteins,
pubmed-meshheading:9383334-Esterification,
pubmed-meshheading:9383334-Mice,
pubmed-meshheading:9383334-Mice, Inbred C57BL,
pubmed-meshheading:9383334-Mice, Mutant Strains,
pubmed-meshheading:9383334-Microphthalmia-Associated Transcription Factor,
pubmed-meshheading:9383334-Microscopy, Electron, Scanning,
pubmed-meshheading:9383334-Microsomes, Liver,
pubmed-meshheading:9383334-Mutation,
pubmed-meshheading:9383334-Pigment Epithelium of Eye,
pubmed-meshheading:9383334-Time Factors,
pubmed-meshheading:9383334-Transcription Factors,
pubmed-meshheading:9383334-Tretinoin,
pubmed-meshheading:9383334-Vitamin A,
pubmed-meshheading:9383334-Vitiligo
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pubmed:year |
1997
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pubmed:articleTitle |
Analysis of esterification of retinoids in the retinal pigmented epithelium of the Mitf-vit (vitiligo) mutant mouse.
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pubmed:affiliation |
Department of Cellular Biology and Anatomy, Medical College of Georgia, Augusta, Georgia 30912-2000, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, U.S. Gov't, Non-P.H.S.,
Research Support, Non-U.S. Gov't
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