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rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
3
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|
pubmed:dateCreated |
1997-11-12
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|
pubmed:abstractText |
The integrin alpha 4 beta 7 and mucosal addressin cell adhesion molecule-1 (MAdCAM-1) are molecules involved in the normal recirculation of lymphocytes between the blood and the gastrointestinal tract. These molecules may play a complementary and significant role in animal models of colitis. We have investigated the structural interaction between alpha 4 beta 7 and MAdCAM-1. Site-directed mutagenesis studies of the MAdCAM-1 molecule has led to the identification of the amino acid residue (LDT) in the loop between beta strands C and D of the Ig-superfamily-like folds being involved in the adhesive and cell activation functions of MAdCAM-1 with alpha 4 beta 7.
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pubmed:language |
eng
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|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
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|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
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|
pubmed:issn |
0257-277X
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|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
16
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
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pubmed:pagination |
299-311
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|
pubmed:dateRevised |
2005-11-21
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|
pubmed:meshHeading |
pubmed-meshheading:9379078-Amino Acid Sequence,
pubmed-meshheading:9379078-Animals,
pubmed-meshheading:9379078-Colitis,
pubmed-meshheading:9379078-Humans,
pubmed-meshheading:9379078-Immunoglobulins,
pubmed-meshheading:9379078-Integrins,
pubmed-meshheading:9379078-Molecular Sequence Data,
pubmed-meshheading:9379078-Mucoproteins,
pubmed-meshheading:9379078-Mutagenesis, Site-Directed,
pubmed-meshheading:9379078-Receptors, Lymphocyte Homing,
pubmed-meshheading:9379078-Structure-Activity Relationship
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|
pubmed:year |
1997
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|
pubmed:articleTitle |
Mucosal addressin cell adhesion molecule-1 (MAdCAM-1). Its binding motif for alpha 4 beta 7 and role in experimental colitis.
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|
pubmed:affiliation |
Department of Immunology, Genentech, Inc., San Francisco, CA 94080-4990, USA. fong.sherman@gene.com
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pubmed:publicationType |
Journal Article,
Review
|
