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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
1997-11-7
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pubmed:abstractText |
Murine intestinal intraepithelial lymphocytes (IELs) consist of T cells bearing alpha beta-antigen receptor (alpha beta-IELs) and those bearing gamma delta-IELs). Although gamma delta-IELs outnumber alpha beta-IELs in germ-free (GF) mice, oral inoculation of fecal suspension from conventional (CV) mice into GF mice induced the increase in number of alpha beta-IELs, leaving the number of gamma delta-IELs unchanged, and the number of alpha beta-IELs reached the level of CV mice by 3 weeks after conventionalization. Expansion of alpha beta-IELs and increase in their CD44+ subset in conventionalized mice were not affected until 2 weeks after beginning of daily injection of cyclosporin A (CsA). However, further expansion of alpha beta-IELs during 2-3 weeks after conventionalization was blocked by injection of CsA. Although the relative constitution of CD4- 8-, CD4+ 8-, CD4- 8 alpha alpha+, CD4- 8 alpha beta+ and CD4+ 8+ subsets among alpha beta-IELs was comparable between control and CsA-treated groups, CsA injection resulted in the decrease in ratio of high-density fraction cells to low density fraction cells in IELs. CsA completely abrogated the expansion of T cells in peripheral lymph nodes stimulated by alloantigens in vivo, and proliferation of IELs from GF mice induced by immobilized anti-alpha beta-T-cell receptor (TCR) monoclonal antibodies (mAb) in vitro was also eliminated by CsA. These results indicate that microbial colonization-induced expansion of alpha beta-IELs is subdivided into two steps: the early phase of expansion takes place via TCR-non-mediated pathway and the late phase of expansion requires TCR-mediated signal transduction.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/9378505-1346234,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9378505-1375473,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9378505-1385155,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9378505-1535367,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9378505-1716278,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9378505-1716785,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9378505-1824857,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9378505-2141628,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9378505-2572671,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9378505-3106474,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9378505-7594578,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9378505-7597094,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9378505-7688787,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9378505-7835925,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9378505-7931068,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9378505-7969453,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9378505-8091211,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9378505-8206090,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9378505-8223444,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9378505-8270881,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9378505-8378333,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9378505-8383994,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9378505-8391987,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9378505-8469988,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9378505-8609387,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9378505-8625988,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9378505-8943725
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD44,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclosporine,
http://linkedlifedata.com/resource/pubmed/chemical/Immunosuppressive Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Isoantigens,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Antigen, T-Cell...,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Antigen, T-Cell...
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0019-2805
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
91
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
628-34
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:9378505-Animals,
pubmed-meshheading:9378505-Antigens, CD44,
pubmed-meshheading:9378505-Cell Division,
pubmed-meshheading:9378505-Cyclosporine,
pubmed-meshheading:9378505-Female,
pubmed-meshheading:9378505-Germ-Free Life,
pubmed-meshheading:9378505-Immunosuppressive Agents,
pubmed-meshheading:9378505-Intestinal Mucosa,
pubmed-meshheading:9378505-Isoantigens,
pubmed-meshheading:9378505-Lymphocyte Activation,
pubmed-meshheading:9378505-Male,
pubmed-meshheading:9378505-Mice,
pubmed-meshheading:9378505-Mice, Inbred BALB C,
pubmed-meshheading:9378505-Mice, Inbred C57BL,
pubmed-meshheading:9378505-Receptors, Antigen, T-Cell, alpha-beta,
pubmed-meshheading:9378505-Receptors, Antigen, T-Cell, gamma-delta,
pubmed-meshheading:9378505-T-Lymphocyte Subsets
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pubmed:year |
1997
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pubmed:articleTitle |
A step-wise expansion of intestinal intraepithelial T lymphocytes in association with microbial colonization is defined by sensitivity to cyclosporin A.
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pubmed:affiliation |
Yakult Central Institute for Microbiological Research, Tokyo, Japan.
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pubmed:publicationType |
Journal Article
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