Linked Life Data

9378177

Source:http://linkedlifedata.com/resource/pubmed/id/9378177

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1997-11-5
pubmed:abstractText
We have conducted a review of the literature on chemical exposures (known carcinogens), mutations in oncogenes/tumor suppressor genes and the occurrence of malignancies. The underlying hypothesis of the studies on this issue is that specific carcinogenic chemicals induce specific mutations in relevant genes ("fingerprints") and that the latter are involved in the causal pathway that leads to cancer. The confirmation of such hypothesis is conditioned by limitations of the available techniques, and by the design of the epidemiological studies. We discuss methodological problems inherent in the identification of oncogene mutations within studies in humans, such as the limited sensitivity of molecular techniques, which may lead to a bias toward the null. Although several studies--concerning mainly lung or bladder cancer and tobacco smoking or some occupational exposures--give support to the theory of "fingerprints", further evidence is warranted.
pubmed:language
ita
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
1120-9763
pubmed:author
pubmed:issnType
Print
pubmed:volume
21
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
106-13
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:articleTitle
[Genetic damage in human tumors associated with particular behavioral or occupational exposures].
pubmed:affiliation
Scuola Specializzazione in Oncologia, Università degli Studi, Torino.
pubmed:publicationType
Journal Article, English Abstract, Review