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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
13
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pubmed:dateCreated |
1997-11-7
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pubmed:abstractText |
Cyclooxygenase-2 (COX-2) is considered to play a major role in inflammation processes by catalyzing the production of prostaglandins (PGs). Using in situ hybridization histochemistry we studied the localization of COS-1 and COX-2 mRNA in the spinal cord and dorsal root ganglia (DRGs) after peripheral inflammation or after axotomy in the rat. No COX-2 mRNA signals were detected in the spinal cord under normal conditions, but strong expression was seen bilaterally in non-neuronal cells within the grey and white matter and along the leptomeninges and blood vessels 6 h after unilateral carrageenan injection into the hind paw, but not after peripheral nerve injury. The results suggest that COX-2 expressed in non-neuronal cells contributes to PG production in and around the spinal cord under peripheral inflammatory processes.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0959-4965
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
8
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pubmed:volume |
8
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2949-52
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:9376536-Animals,
pubmed-meshheading:9376536-Axotomy,
pubmed-meshheading:9376536-Carrageenan,
pubmed-meshheading:9376536-Cyclooxygenase 2,
pubmed-meshheading:9376536-Ganglia, Spinal,
pubmed-meshheading:9376536-Hindlimb,
pubmed-meshheading:9376536-Histocytochemistry,
pubmed-meshheading:9376536-In Situ Hybridization,
pubmed-meshheading:9376536-Inflammation,
pubmed-meshheading:9376536-Injections,
pubmed-meshheading:9376536-Isoenzymes,
pubmed-meshheading:9376536-Lumbosacral Region,
pubmed-meshheading:9376536-Male,
pubmed-meshheading:9376536-Prostaglandin-Endoperoxide Synthases,
pubmed-meshheading:9376536-RNA, Messenger,
pubmed-meshheading:9376536-Rats,
pubmed-meshheading:9376536-Rats, Sprague-Dawley,
pubmed-meshheading:9376536-Sciatic Nerve,
pubmed-meshheading:9376536-Spinal Cord
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pubmed:year |
1997
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pubmed:articleTitle |
Increased levels of cyclooxygenase-2 mRNA in the rat spinal cord after peripheral inflammation: an in situ hybridization study.
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pubmed:affiliation |
Department of Neuroscience, Karolinska Institute, Stockholm, Sweden.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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