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rdf:type |
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lifeskim:mentions |
umls-concept:C0006141,
umls-concept:C0008643,
umls-concept:C0392360,
umls-concept:C0442821,
umls-concept:C0596263,
umls-concept:C0796345,
umls-concept:C1283195,
umls-concept:C1314939,
umls-concept:C1442161,
umls-concept:C1953345,
umls-concept:C1999230
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pubmed:issue |
8
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pubmed:dateCreated |
1997-11-12
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pubmed:abstractText |
We have identified a high frequency of loss of heterozygosity (LOH) on the human chromosome region 8p12-p22 in a panel of microdissected familial (86% LOH) and sporadic (74% LOH) breast tumours. The two most frequently deleted regions were defined around marker D8S133 and in a broader centromeric region bounded by markers D8S137 and D8S339. We cannot unequivocally characterize the 8p12-p22 loss as an early or a late event in breast carcinogenesis. In parallel, we have performed linkage analysis in four German breast cancer families. A location score greater than 13.67 corresponding to a LOD score of 2.97 at the marker D8S137 has been obtained. Our results considerably strengthen the evidence for a breast cancer susceptibility gene(s) located on the short arm of the chromosome region at 8p12-p22.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/9376278-1356616,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9376278-1990835,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9376278-7493020,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9376278-7519868,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9376278-7519877,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9376278-7585541,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9376278-7585607,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9376278-7669736,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9376278-7669738,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9376278-7687457,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9376278-7850795,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9376278-7898921,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9376278-8097582,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9376278-8162568,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9376278-8187088,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9376278-8317490,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9376278-8364930,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9376278-8460645,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9376278-8479756,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9376278-8485726,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9376278-8570218,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9376278-8600387,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9376278-8602509,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9376278-8622901,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9376278-8625320,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9376278-8649800,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9376278-8661103,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9376278-8751389,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9376278-8786118,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9376278-8814452,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9376278-8900426,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9376278-9038382
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:status |
MEDLINE
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pubmed:issn |
0007-0920
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pubmed:author |
pubmed-author:BenderEE,
pubmed-author:El-ZehairyAA,
pubmed-author:HaenschWW,
pubmed-author:JandrigBB,
pubmed-author:KölbleKK,
pubmed-author:NothnagelAA,
pubmed-author:PiddeHH,
pubmed-author:RohdeKK,
pubmed-author:ScherneckSS,
pubmed-author:SchlagP MPM,
pubmed-author:SeitzSS,
pubmed-author:UllrichO MOM
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pubmed:issnType |
Print
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pubmed:volume |
76
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
983-91
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:9376278-Adult,
pubmed-meshheading:9376278-Aged,
pubmed-meshheading:9376278-Breast Neoplasms,
pubmed-meshheading:9376278-Chromosome Mapping,
pubmed-meshheading:9376278-Chromosomes, Human, Pair 8,
pubmed-meshheading:9376278-Family Health,
pubmed-meshheading:9376278-Female,
pubmed-meshheading:9376278-Gene Deletion,
pubmed-meshheading:9376278-Genetic Linkage,
pubmed-meshheading:9376278-Humans,
pubmed-meshheading:9376278-Loss of Heterozygosity,
pubmed-meshheading:9376278-Microsatellite Repeats,
pubmed-meshheading:9376278-Middle Aged
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pubmed:year |
1997
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pubmed:articleTitle |
Deletion mapping and linkage analysis provide strong indication for the involvement of the human chromosome region 8p12-p22 in breast carcinogenesis.
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pubmed:affiliation |
Department of Tumour Genetics, Max Delbrueck Center for Molecular Medicine Berlin, Germany.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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