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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5 Pt 1
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pubmed:dateCreated |
1997-12-17
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pubmed:abstractText |
The effects of capsaicin and neuropeptides were examined in equine tracheal smooth muscle (TSM). Neither capsaicin nor substance P (SP) contracted TSM. Capsaicin (100 microM) elicited relaxation in TSM contracted with methacholine. This relaxation was not mimicked by SP or calcitonin gene-related peptide (CGRP). Relaxation was not attenuated by removal of the epithelium or by pretreatment of tissue with meclofenamate or the nitric oxide (NO) synthase inhibitor NG-nitro-L-arginine. Previous exposure of TSM to capsaicin did not eliminate the relaxation responses to subsequent capsaicin. Although vasoactive intestinal peptide (VIP) elicited marked relaxation that was attenuated by alpha-chymotrypsin, alpha-chymotrypsin did not affect the capsaicin-induced relaxation. Capsaicin-induced relaxation was abolished by charybdotoxin, a blocker of large-conductance Ca(2+)-activated K+ channels. These results indicate that capsaicin-induced equine TSM relaxation is not mediated either by neuropeptides such as SP or CGRP released from capsaicin-sensitive sensory nerves or by prostanoids, NO, or VIP. Relaxation is due to the effect of capsaicin on large-conductance Ca(2+)-activated K+ channels. The peptidergic nerves play no important role in the regulation of TSM tone in horse airways.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Calcitonin Gene-Related Peptide,
http://linkedlifedata.com/resource/pubmed/chemical/Capsaicin,
http://linkedlifedata.com/resource/pubmed/chemical/Charybdotoxin,
http://linkedlifedata.com/resource/pubmed/chemical/Chymotrypsin,
http://linkedlifedata.com/resource/pubmed/chemical/Large-Conductance...,
http://linkedlifedata.com/resource/pubmed/chemical/Methacholine Chloride,
http://linkedlifedata.com/resource/pubmed/chemical/Neuropeptides,
http://linkedlifedata.com/resource/pubmed/chemical/Nitric Oxide,
http://linkedlifedata.com/resource/pubmed/chemical/Nitroarginine,
http://linkedlifedata.com/resource/pubmed/chemical/Potassium Channel Blockers,
http://linkedlifedata.com/resource/pubmed/chemical/Potassium Channels...,
http://linkedlifedata.com/resource/pubmed/chemical/Substance P,
http://linkedlifedata.com/resource/pubmed/chemical/Vasoactive Intestinal Peptide
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0002-9513
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
273
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
L997-1001
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:9374726-Animals,
pubmed-meshheading:9374726-Calcitonin Gene-Related Peptide,
pubmed-meshheading:9374726-Capsaicin,
pubmed-meshheading:9374726-Charybdotoxin,
pubmed-meshheading:9374726-Chymotrypsin,
pubmed-meshheading:9374726-Epithelial Cells,
pubmed-meshheading:9374726-Horses,
pubmed-meshheading:9374726-Large-Conductance Calcium-Activated Potassium Channels,
pubmed-meshheading:9374726-Methacholine Chloride,
pubmed-meshheading:9374726-Muscle, Smooth,
pubmed-meshheading:9374726-Muscle Contraction,
pubmed-meshheading:9374726-Muscle Relaxation,
pubmed-meshheading:9374726-Neurons, Afferent,
pubmed-meshheading:9374726-Neuropeptides,
pubmed-meshheading:9374726-Nitric Oxide,
pubmed-meshheading:9374726-Nitroarginine,
pubmed-meshheading:9374726-Potassium Channel Blockers,
pubmed-meshheading:9374726-Potassium Channels, Calcium-Activated,
pubmed-meshheading:9374726-Substance P,
pubmed-meshheading:9374726-Trachea,
pubmed-meshheading:9374726-Vasoactive Intestinal Peptide
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pubmed:year |
1997
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pubmed:articleTitle |
Mechanism of capsaicin-induced relaxation in equine tracheal smooth muscle.
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pubmed:affiliation |
Department of Large Animal Clinical Sciences, Michigan State University, East Lansing 48824-1314, USA.
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pubmed:publicationType |
Journal Article,
In Vitro
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