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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
10
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pubmed:dateCreated |
1997-12-4
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pubmed:abstractText |
Thymic epithelial tumours are broadly classified into thymomas and thymic carcinomas. Although both tumours occasionally show invasive growth, they exhibit different clinical and biological findings. The oncogene and anti-oncogene in thymic epithelial tumours have not been evaluated fully. We investigated the expression of p53 protein by immunohistochemical analysis using the anti-p53 polyclonal antibody (CM-1) in 17 thymomas and 19 thymic carcinomas. We also examined p53 gene (exon 5-8) mutation in 18 thymic carcinomas by using polymerase chain reaction-single-strand conformation polymorphism methods and direct sequencing. Of the thymoma cases, only one invasive thymoma showed focal nuclear staining. Fourteen of the 19 thymic carcinomas (74%) showed nuclear staining. Point mutations of the p53 gene were recognized in only 2 of the 18 thymic carcinomas (11%). One was the mutation C to T transition in the first letter of codon 222 in exon 6, which results in the amino acid substitution from proline to serine. Another was a silent mutation. p53 protein accumulation is highly frequent in thymic carcinomas but not in thymomas, and gene mutation is uncommon in thymic carcinomas.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/9374384-1323840,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9374384-1348931,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9374384-1463094,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9374384-1476794,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9374384-1535557,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9374384-1559236,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9374384-1569122,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9374384-1689123,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9374384-1709656,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9374384-1905840,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9374384-1923535,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9374384-1991250,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9374384-2252104,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9374384-2420219,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9374384-3202120,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9374384-3789252,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9374384-602973,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9374384-7296496,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9374384-7506924,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9374384-7572785,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9374384-7629292,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9374384-7704323,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9374384-7931827,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9374384-8033031,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9374384-8103295,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/9374384-8892596
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
0007-0920
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
76
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1361-6
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:9374384-Adult,
pubmed-meshheading:9374384-Aged,
pubmed-meshheading:9374384-Aged, 80 and over,
pubmed-meshheading:9374384-Female,
pubmed-meshheading:9374384-Humans,
pubmed-meshheading:9374384-Immunohistochemistry,
pubmed-meshheading:9374384-Male,
pubmed-meshheading:9374384-Middle Aged,
pubmed-meshheading:9374384-Mutation,
pubmed-meshheading:9374384-Nuclear Proteins,
pubmed-meshheading:9374384-Proto-Oncogene Proteins,
pubmed-meshheading:9374384-Proto-Oncogene Proteins c-mdm2,
pubmed-meshheading:9374384-Thymoma,
pubmed-meshheading:9374384-Thymus Neoplasms,
pubmed-meshheading:9374384-Tumor Suppressor Protein p53
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pubmed:year |
1997
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pubmed:articleTitle |
High frequency of p53 protein expression in thymic carcinoma but not in thymoma.
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pubmed:affiliation |
Second Department of Surgery, School of Medicine, The University of Tokushima, Japan.
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pubmed:publicationType |
Journal Article
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