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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
1998-1-5
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pubmed:abstractText |
Antibody-based reagents have failed to live up to their anticipated role as highly specific targeting agents for cancer therapy. Targeting with human single-chain Fv (sFv) molecules may overcome some of the limitations of murine IgG, but are difficult to produce with conventional hybridoma technology. Alternatively, phage display of antibody gene repertoires can be used to produce human sFv.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
1380-2933
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
1
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pubmed:owner |
NLM
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pubmed:authorsComplete |
N
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pubmed:pagination |
73-81
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:9373335-Amino Acid Sequence,
pubmed-meshheading:9373335-Animals,
pubmed-meshheading:9373335-CHO Cells,
pubmed-meshheading:9373335-Cricetinae,
pubmed-meshheading:9373335-Enzyme-Linked Immunosorbent Assay,
pubmed-meshheading:9373335-Humans,
pubmed-meshheading:9373335-Immunoglobulin Fragments,
pubmed-meshheading:9373335-Immunoglobulin Heavy Chains,
pubmed-meshheading:9373335-Immunoglobulin Light Chains,
pubmed-meshheading:9373335-Immunoglobulin Variable Region,
pubmed-meshheading:9373335-Mice,
pubmed-meshheading:9373335-Mice, SCID,
pubmed-meshheading:9373335-Molecular Sequence Data,
pubmed-meshheading:9373335-Peptide Library,
pubmed-meshheading:9373335-Receptor, erbB-2,
pubmed-meshheading:9373335-Recombinant Proteins
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pubmed:year |
1995
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pubmed:articleTitle |
In vitro and in vivo characterization of a human anti-c-erbB-2 single-chain Fv isolated from a filamentous phage antibody library.
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pubmed:affiliation |
Department of Anesthesia and Pharmaceutical Chemistry, University of California, San Francisco, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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