| pubmed-article:9372544 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9372544 | lifeskim:mentions | umls-concept:C0001483 | lld:lifeskim |
| pubmed-article:9372544 | lifeskim:mentions | umls-concept:C1522449 | lld:lifeskim |
| pubmed-article:9372544 | lifeskim:mentions | umls-concept:C1533685 | lld:lifeskim |
| pubmed-article:9372544 | lifeskim:mentions | umls-concept:C0237753 | lld:lifeskim |
| pubmed-article:9372544 | lifeskim:mentions | umls-concept:C0314603 | lld:lifeskim |
| pubmed-article:9372544 | lifeskim:mentions | umls-concept:C0205217 | lld:lifeskim |
| pubmed-article:9372544 | lifeskim:mentions | umls-concept:C2349975 | lld:lifeskim |
| pubmed-article:9372544 | pubmed:issue | 5 | lld:pubmed |
| pubmed-article:9372544 | pubmed:dateCreated | 1997-12-23 | lld:pubmed |
| pubmed-article:9372544 | pubmed:abstractText | Intratumoral injection of an adenoviral vector containing radiation-inducible DNA sequences of the early growth response gene (Egr-1) promoter ligated to a cDNA encoding tumor necrosis factor-alpha (TNF-alpha; Ad.Egr-TNF) increases the radiation killing of a human radioresistant xenograft (SQ-20B). Viral dose-escalation experiments demonstrated that SQ-20B growth inhibition correlated with viral titer. Injection of 5 x 10(8) PFU Ad.Egr-TNF produced regression to a mean volume of 22 +/- 13% of the original tumor volume, 1 x 10(8) PFU to a mean of 62 +/- 24%, and 5 x 10(7) PFU to a mean of 67 +/- 27%. No regression was observed when tumors were injected with 1 x 10(7) PFU Ad.Egr-TNF or with the null viral vector (Ad.null). When two injections of vector (2 x 10(8) PFU Ad.Egr-TNF) were combined with 50 Gy, a significant increase in tumor regression was observed compared with injection of buffer, Ad.Egr-TNF, or 50 Gy. The interactive killing between TNF and radiation was enhanced significantly (P = 0.05) when the number of injections was increased from two to five while maintaining a constant viral titer (2 x 10(8) PFU Ad.Egr-TNF) and a constant radiation dose (50 Gy). Significant TNF-alpha levels were present in irradiated vs. unirradiated tumors following injection with Ad.Egr-TNF. Taken together, these data suggest that the volumetric reduction produced by the combined effects of Ad.Egr-TNF and radiation is enhanced with increasing vector concentration and the number of vector injections. | lld:pubmed |
| pubmed-article:9372544 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9372544 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9372544 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9372544 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9372544 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9372544 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:9372544 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9372544 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9372544 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9372544 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9372544 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9372544 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9372544 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9372544 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9372544 | pubmed:issn | 1065-7541 | lld:pubmed |
| pubmed-article:9372544 | pubmed:author | pubmed-author:WeichselbaumR... | lld:pubmed |
| pubmed-article:9372544 | pubmed:author | pubmed-author:MauceriH JHJ | lld:pubmed |
| pubmed-article:9372544 | pubmed:author | pubmed-author:SeungL PLP | lld:pubmed |
| pubmed-article:9372544 | pubmed:author | pubmed-author:GrdinaW LWL | lld:pubmed |
| pubmed-article:9372544 | pubmed:author | pubmed-author:SwedbergK AKA | lld:pubmed |
| pubmed-article:9372544 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9372544 | pubmed:volume | 5 | lld:pubmed |
| pubmed-article:9372544 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9372544 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9372544 | pubmed:pagination | 220-6 | lld:pubmed |
| pubmed-article:9372544 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
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| pubmed-article:9372544 | pubmed:meshHeading | pubmed-meshheading:9372544-... | lld:pubmed |
| pubmed-article:9372544 | pubmed:year | 1997 | lld:pubmed |
| pubmed-article:9372544 | pubmed:articleTitle | Increased injection number enhances adenoviral genetic radiotherapy. | lld:pubmed |
| pubmed-article:9372544 | pubmed:affiliation | Department of Radiation and Cellular Oncology, Pritzker School of Medicine, University of Chicago, USA. | lld:pubmed |
| pubmed-article:9372544 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:9372544 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:9372544 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
