Linked Life Data

9371982

Source:http://linkedlifedata.com/resource/pubmed/id/9371982

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1998-1-14
pubmed:abstractText
The study of erythropoietin gene expression provides a paradigm for understanding gene regulation in response to hypoxia. The sensor for detecting alterations in oxygen tension appears to be a heme protein. Ongoing transcription and protein synthesis are necessary for hypoxic induction of erythropoietin messenger RNA. In the past few years, considerable progress has been made in the identification and characterization of cis-acting elements and trans-acting factors that contribute to erythropoietin gene expression. The erythropoietin promoter and 3' enhancer function synergistically in response to hypoxia. Whereas hypoxia-inducible factor 1 specifically binds to the 3' enhancer conferring hypoxic induction, hepatic nuclear factor 4 interacts with the promoter as well as the 3' enhancer for stimulus- and tissue-specific induction of the erythropoietin gene. In addition, a segment in the 3' untranslated region contributes to the relatively rapid turnover of erythropoietin messenger RNA.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
1065-6251
pubmed:author
pubmed:issnType
Print
pubmed:volume
2
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
125-31
pubmed:dateRevised
2005-11-16
pubmed:meshHeading
pubmed:year
1995
pubmed:articleTitle
Regulation of erythropoietin gene expression.
pubmed:affiliation
Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
pubmed:publicationType
Journal Article, Review