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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
22
|
| pubmed:dateCreated |
1997-12-1
|
| pubmed:abstractText |
8-Chloro-cAMP (8-Cl-cAMP) is a novel agent that is able to inhibit the growth of a wide variety of cancer cell types in vitro and in vivo and, at doses devoid of toxicity, to achieve plasma concentrations in cancer patients in a range effective for cancer cell growth inhibition. In this study, we have demonstrated that 8-Cl-cAMP, at a dose causing mild or no growth inhibition, synergistically increased the growth-inhibitory effect of paclitaxel or cisplatin in a wide series of cell lines including human breast, lung, ovary, colon, and head carcinomas and melanoma. A similar effect was also observed with another taxane, docetaxel, and with the platinum-derivative carboplatin. 8-Cl-cAMP also markedly enhanced apoptotic cell death induced by each cytotoxic drug. A cooperative antitumor effect was also observed in vivo, because treatment with paclitaxel followed by 8-Cl-cAMP markedly inhibited the growth of GEO human colon cancer xenografts as compared to paclitaxel alone without signs of toxicity. These data demonstrate that 8-Cl-cAMP synergistically increases the antiproliferative activity of taxanes and platinum-derived compounds and provide a rationale to use 8-Cl-cAMP in combination with taxanes and platinum-derived compounds.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/8-Bromo Cyclic Adenosine...,
http://linkedlifedata.com/resource/pubmed/chemical/8-chloro-cyclic adenosine...,
http://linkedlifedata.com/resource/pubmed/chemical/Antineoplastic Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Cisplatin,
http://linkedlifedata.com/resource/pubmed/chemical/Paclitaxel
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Nov
|
| pubmed:issn |
0008-5472
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
15
|
| pubmed:volume |
57
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
5107-11
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:9371510-8-Bromo Cyclic Adenosine Monophosphate,
pubmed-meshheading:9371510-Animals,
pubmed-meshheading:9371510-Antineoplastic Agents,
pubmed-meshheading:9371510-Apoptosis,
pubmed-meshheading:9371510-Cell Division,
pubmed-meshheading:9371510-Cisplatin,
pubmed-meshheading:9371510-Drug Synergism,
pubmed-meshheading:9371510-Female,
pubmed-meshheading:9371510-G2 Phase,
pubmed-meshheading:9371510-Humans,
pubmed-meshheading:9371510-Mice,
pubmed-meshheading:9371510-Mice, Inbred BALB C,
pubmed-meshheading:9371510-Mice, Nude,
pubmed-meshheading:9371510-Mitosis,
pubmed-meshheading:9371510-Neoplasm Transplantation,
pubmed-meshheading:9371510-Paclitaxel,
pubmed-meshheading:9371510-Transplantation, Heterologous,
pubmed-meshheading:9371510-Tumor Cells, Cultured,
pubmed-meshheading:9371510-Tumor Stem Cell Assay
|
| pubmed:year |
1997
|
| pubmed:articleTitle |
Synergistic inhibition of growth and induction of apoptosis by 8-chloro-cAMP and paclitaxel or cisplatin in human cancer cells.
|
| pubmed:affiliation |
Dipartimento di Endocrinologia e Oncologia Molecolare e Clinica, Facoltà di Medicina e Chirurgia, Università degli Studi di Napoli Federico II, Naples, Italy.
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|