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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
10
|
| pubmed:dateCreated |
1997-12-22
|
| pubmed:abstractText |
Postprandial substrate and hormone responses to a standard mixed meal (400 kcal) was determined at two occasions, A and B, in 11 women with gestational diabetes (GDMs) and 11 normoglycaemic controls, matched for age, body mass index, and gestational age. Levels of circulating glucose, non-esterified fatty acids (NEFA), glycerol, 3-hydroxybutyrate (3-HBA), individual amino acids, insulin, and C-peptide were analysed. A was performed when GDMs were considered inadequately controlled with diet alone, B later during gestation following initiation of insulin therapy because of hyperglycaemia. Fasting glucose, glycerol, total and individual amino acids (alanine, valine, isoleucine, leucine), insulin, and C-peptide were not different from normal during A and B, neither were postprandial amino acid levels. During test A, GDMs had elevated fasting and postprandial 3-HBA (p < 0.001), greater postprandial rise of glucose (p < 0.001), elevated NEFA (p < 0.05), but normal and parallel decreases of NEFA and glycerol. Insulin and C-peptide responses were delayed and prolonged. During B, GDMs had higher glucose response (p < 0.005), higher fasting 3-HBA (p < 0.02) but similar and parallel decreases of NEFA, glycerol, and 3-HBA as controls. The C-peptide response was not significantly different from normal; insulin response was higher (p < 0.05). In conclusion, the relative insulin deficiency characterizing GDMs, also when treated with insulin, is associated with selected defects in insulin action; mainly affecting glucoregulation, whereas suppression of lipolysis and proteolysis remain normal.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/3-Hydroxybutyric Acid,
http://linkedlifedata.com/resource/pubmed/chemical/Amino Acids,
http://linkedlifedata.com/resource/pubmed/chemical/Blood Glucose,
http://linkedlifedata.com/resource/pubmed/chemical/C-Peptide,
http://linkedlifedata.com/resource/pubmed/chemical/Fatty Acids, Nonesterified,
http://linkedlifedata.com/resource/pubmed/chemical/Glycerol,
http://linkedlifedata.com/resource/pubmed/chemical/Hydroxybutyrates,
http://linkedlifedata.com/resource/pubmed/chemical/Hypoglycemic Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Insulin
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Oct
|
| pubmed:issn |
0742-3071
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
14
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
841-8
|
| pubmed:dateRevised |
2011-11-17
|
| pubmed:meshHeading |
pubmed-meshheading:9371476-3-Hydroxybutyric Acid,
pubmed-meshheading:9371476-Adolescent,
pubmed-meshheading:9371476-Adult,
pubmed-meshheading:9371476-Amino Acids,
pubmed-meshheading:9371476-Blood Glucose,
pubmed-meshheading:9371476-Body Mass Index,
pubmed-meshheading:9371476-C-Peptide,
pubmed-meshheading:9371476-Diabetes, Gestational,
pubmed-meshheading:9371476-Diabetic Diet,
pubmed-meshheading:9371476-Energy Intake,
pubmed-meshheading:9371476-Fatty Acids, Nonesterified,
pubmed-meshheading:9371476-Female,
pubmed-meshheading:9371476-Gestational Age,
pubmed-meshheading:9371476-Glycerol,
pubmed-meshheading:9371476-Humans,
pubmed-meshheading:9371476-Hydroxybutyrates,
pubmed-meshheading:9371476-Hypoglycemic Agents,
pubmed-meshheading:9371476-Insulin,
pubmed-meshheading:9371476-Postprandial Period,
pubmed-meshheading:9371476-Pregnancy,
pubmed-meshheading:9371476-Reference Values,
pubmed-meshheading:9371476-Time Factors
|
| pubmed:year |
1997
|
| pubmed:articleTitle |
Assessment of therapy in gestational diabetes by substrate and hormone responses to a standardized test meal.
|
| pubmed:affiliation |
Department of Woman and Child Health, Karolinska Hospital, Karolinska Institute, Stockholm, Sweden.
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|