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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
1998-1-21
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pubmed:abstractText |
Dp71, a 71 kDa C-terminal isoform of dystrophin, is the major product of the DMD gene in brain. Two alternatively spliced transcripts of Dp71 were amplified by RT-PCR from different areas of human fetal neural tissue. Both transcripts were spliced out of exons 71 and 78. The shorter transcript was also alternatively spliced of exons 72-74, a region comprising the coding sequence for the binding site to syntrophin, one component of the dystrophin-associated protein complex. Results indicate that alternatively spliced forms of Dp71 are regulated during human neural development.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0165-3806
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
20
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pubmed:volume |
103
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
77-82
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:9370062-Alternative Splicing,
pubmed-meshheading:9370062-Binding Sites,
pubmed-meshheading:9370062-Brain,
pubmed-meshheading:9370062-Dystrophin,
pubmed-meshheading:9370062-Dystrophin-Associated Proteins,
pubmed-meshheading:9370062-Embryonic and Fetal Development,
pubmed-meshheading:9370062-Exons,
pubmed-meshheading:9370062-Gene Expression Regulation, Developmental,
pubmed-meshheading:9370062-Genetic Variation,
pubmed-meshheading:9370062-Humans,
pubmed-meshheading:9370062-Membrane Proteins,
pubmed-meshheading:9370062-Muscle Proteins,
pubmed-meshheading:9370062-Polymerase Chain Reaction,
pubmed-meshheading:9370062-Recombinant Proteins,
pubmed-meshheading:9370062-Transcription, Genetic
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pubmed:year |
1997
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pubmed:articleTitle |
A splice variant of Dp71 lacking the syntrophin binding site is expressed in early stages of human neural development.
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pubmed:affiliation |
Laboratorio di Biologia Cellulare, Istituto Superiore di Sanità, Rome, Italy. mceccarini@net.iss.it
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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