Linked Life Data

9368955

Source:http://linkedlifedata.com/resource/pubmed/id/9368955

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1998-2-3
pubmed:abstractText
An immunohistochemical characterisation of neoplastic cells and peritumoural cellular infiltrate of ovine squamous cell carcinomas (OSCC) in different stages of growth was carried out using a commercially-available panel of seven antibodies, and formalin-fixed and paraffin-embedded tissue samples. Neoplastic cells reacted with the anti-keratin monoclonal antibody RCK-102 and with an anti-keratin polyclonal antibody, whereas they were unreactive with the anti-keratin monoclonal antibody NCL-5D3. The tumour cells were unreactive with the anti-vimentin polyclonal antibody. Increased numbers of CD3+ T-lymphocytes, IgG-containing plasma cells and lysozyme+ macrophages were associated with precancerous lesions (actinic keratosis) and with early OSCC. These results show that early lesions of OSCC induce an in situ cellular and humoral immune response. In advanced OSCC, the number of CD3+ T-lymphocytes and macrophages in the peri- and intratumoural cellular infiltrate remained high, whereas a significant decrease of IgG-containing plasma cells was found compared with early OSCC. This finding suggests an in situ decrease in the humoral immune response in advanced OSCC.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0034-5288
pubmed:author
pubmed:issnType
Print
pubmed:volume
63
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
43-7
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:articleTitle
Ovine squamous cell carcinoma: immunocharacterisation of neoplastic cells and peritumoural cellular infiltrate.
pubmed:affiliation
Department of Comparative Pathology, Faculty of Veterinary Medicine, University of Córdoba, Spain.
pubmed:publicationType
Journal Article, Comparative Study