| pubmed-article:9367984 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9367984 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:9367984 | lifeskim:mentions | umls-concept:C0058415 | lld:lifeskim |
| pubmed-article:9367984 | lifeskim:mentions | umls-concept:C0013138 | lld:lifeskim |
| pubmed-article:9367984 | lifeskim:mentions | umls-concept:C0086860 | lld:lifeskim |
| pubmed-article:9367984 | lifeskim:mentions | umls-concept:C0444669 | lld:lifeskim |
| pubmed-article:9367984 | lifeskim:mentions | umls-concept:C0013879 | lld:lifeskim |
| pubmed-article:9367984 | pubmed:issue | 22 | lld:pubmed |
| pubmed-article:9367984 | pubmed:dateCreated | 1997-12-19 | lld:pubmed |
| pubmed-article:9367984 | pubmed:abstractText | We analyzed the function of the downstream promoter element (DPE), a distinct 7-nucleotide core promoter element that is approximately 30 nucleotides downstream of the transcription start site of many TATA-box-deficient (TATA-less) promoters in Drosophila. There is a strict requirement for spacing between the Inr and DPE motifs, as an increase or decrease of 3 nucleotides in the distance between the Inr and DPE causes a seven- to eightfold reduction in transcription as well as a significant reduction in the binding of purified TFIID. These results suggest a specific and somewhat rigid interaction of TFIID with the Inr and DPE sequences. Photo-cross-linking analysis of purified TFIID with a TATA-less DPE-containing promoter revealed specific cross-linking of dTAFII60 and dTAFII40 to the DPE, with a higher efficiency of cross-linking to dTAFII60 than to dTAFII40. These data, combined with the previously well-characterized interactions between the two TAFs and their homology to histones H4 and H3, suggest that a dTAFII60-dTAFII40 heterotetramer binds to the DPE. Human and Drosophila transcription factors exhibit essentially the same requirements for DPE sequence and for Inr-DPE spacing. In addition, the TATA-less promoter of the human interferon regulatory factor-1 (IRF-1) gene contains a DPE that is important for transcriptional activity both in vitro and in cultured cells. Hence, these studies provide evidence for a direct role of TAFs in basal transcription of TATA-less DPE-containing genes and collectively indicate that the DPE is, in many respects, a downstream counterpart to the TATA box that is present in Drosophila to humans. | lld:pubmed |
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| pubmed-article:9367984 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9367984 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9367984 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:9367984 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:9367984 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9367984 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:9367984 | pubmed:issn | 0890-9369 | lld:pubmed |
| pubmed-article:9367984 | pubmed:author | pubmed-author:BurkeT WTW | lld:pubmed |
| pubmed-article:9367984 | pubmed:author | pubmed-author:KadonagaJ TJT | lld:pubmed |
| pubmed-article:9367984 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9367984 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:9367984 | pubmed:volume | 11 | lld:pubmed |
| pubmed-article:9367984 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9367984 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9367984 | pubmed:pagination | 3020-31 | lld:pubmed |
| pubmed-article:9367984 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
| pubmed-article:9367984 | pubmed:meshHeading | pubmed-meshheading:9367984-... | lld:pubmed |
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| pubmed-article:9367984 | pubmed:meshHeading | pubmed-meshheading:9367984-... | lld:pubmed |
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| pubmed-article:9367984 | pubmed:meshHeading | pubmed-meshheading:9367984-... | lld:pubmed |
| pubmed-article:9367984 | pubmed:meshHeading | pubmed-meshheading:9367984-... | lld:pubmed |
| pubmed-article:9367984 | pubmed:year | 1997 | lld:pubmed |
| pubmed-article:9367984 | pubmed:articleTitle | The downstream core promoter element, DPE, is conserved from Drosophila to humans and is recognized by TAFII60 of Drosophila. | lld:pubmed |
| pubmed-article:9367984 | pubmed:affiliation | Department of Biology and Center for Molecular Genetics, University of California, San Diego, La Jolla, California 92093-0347 USA. | lld:pubmed |
| pubmed-article:9367984 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:9367984 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
