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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5342
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pubmed:dateCreated |
1997-12-16
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pubmed:abstractText |
Virus-specific CD4+ T helper lymphocytes are critical to the maintenance of effective immunity in a number of chronic viral infections, but are characteristically undetectable in chronic human immunodeficiency virus-type 1 (HIV-1) infection. In individuals who control viremia in the absence of antiviral therapy, polyclonal, persistent, and vigorous HIV-1-specific CD4+ T cell proliferative responses were present, resulting in the elaboration of interferon-gamma and antiviral beta chemokines. In persons with chronic infection, HIV-1-specific proliferative responses to p24 were inversely related to viral load. Strong HIV-1-specific proliferative responses were also detected following treatment of acutely infected persons with potent antiviral therapy. The HIV-1-specific helper cells are likely to be important in immunotherapeutic interventions and vaccine development.
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pubmed:grant |
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0036-8075
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
21
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pubmed:volume |
278
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1447-50
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:9367954-Amino Acid Sequence,
pubmed-meshheading:9367954-Anti-HIV Agents,
pubmed-meshheading:9367954-Chemokines,
pubmed-meshheading:9367954-Cohort Studies,
pubmed-meshheading:9367954-Cytotoxicity, Immunologic,
pubmed-meshheading:9367954-Disease Progression,
pubmed-meshheading:9367954-Drug Therapy, Combination,
pubmed-meshheading:9367954-HIV Core Protein p24,
pubmed-meshheading:9367954-HIV Envelope Protein gp160,
pubmed-meshheading:9367954-HIV Infections,
pubmed-meshheading:9367954-HIV-1,
pubmed-meshheading:9367954-Humans,
pubmed-meshheading:9367954-Immunologic Memory,
pubmed-meshheading:9367954-Interferon-gamma,
pubmed-meshheading:9367954-Lymphocyte Activation,
pubmed-meshheading:9367954-Molecular Sequence Data,
pubmed-meshheading:9367954-Peptide Fragments,
pubmed-meshheading:9367954-T-Lymphocytes, Cytotoxic,
pubmed-meshheading:9367954-T-Lymphocytes, Helper-Inducer,
pubmed-meshheading:9367954-Viral Load,
pubmed-meshheading:9367954-Viremia,
pubmed-meshheading:9367954-Virus Replication
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pubmed:year |
1997
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pubmed:articleTitle |
Vigorous HIV-1-specific CD4+ T cell responses associated with control of viremia.
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pubmed:affiliation |
Partners AIDS Research Center and Infectious Disease Unit, Massachusetts General Hospital, and Harvard Medical School, Boston, MA 02114, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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