Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
|
| pubmed:dateCreated |
1997-12-15
|
| pubmed:databankReference | |
| pubmed:abstractText |
RING finger is a variant zinc finger motif present in a new family of proteins including transcription regulators. A genomic DNA fragment containing RING finger motifs was identified by the polymerase chain reaction using degenerate primers. Using this fragment as a probe, we have isolated a novel cDNA from rat brain library. The predicted open reading frame contains a RING finger domain at its N-terminal portion. The corresponding transcript was detected predominantly in the brain and therefore was designated brain finger protein (bfp). An antibody raised against a recombinant bfp reveals the presence of the bfp in the brain. Interestingly, the bfp is induced during retinoic acid-mediated differentiation of P19 embryonal carcinoma cells into neural cells. These findings suggest the possible involvement of bfp in some aspects of neural cell regulation.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Nov
|
| pubmed:issn |
0006-291X
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
7
|
| pubmed:volume |
240
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
8-14
|
| pubmed:dateRevised |
2008-11-21
|
| pubmed:meshHeading |
pubmed-meshheading:9367872-Amino Acid Sequence,
pubmed-meshheading:9367872-Animals,
pubmed-meshheading:9367872-Base Sequence,
pubmed-meshheading:9367872-Brain,
pubmed-meshheading:9367872-DNA-Binding Proteins,
pubmed-meshheading:9367872-Embryonal Carcinoma Stem Cells,
pubmed-meshheading:9367872-Gene Expression Regulation, Developmental,
pubmed-meshheading:9367872-Humans,
pubmed-meshheading:9367872-Mice,
pubmed-meshheading:9367872-Molecular Sequence Data,
pubmed-meshheading:9367872-Neoplastic Stem Cells,
pubmed-meshheading:9367872-Nerve Tissue Proteins,
pubmed-meshheading:9367872-Protein Biosynthesis,
pubmed-meshheading:9367872-Proteins,
pubmed-meshheading:9367872-Rats,
pubmed-meshheading:9367872-Tretinoin,
pubmed-meshheading:9367872-Tumor Cells, Cultured,
pubmed-meshheading:9367872-Zinc Fingers
|
| pubmed:year |
1997
|
| pubmed:articleTitle |
A novel RING finger protein, BFP, predominantly expressed in the brain.
|
| pubmed:affiliation |
Department of Biochemistry, Saitama Medical School, Japan.
|
| pubmed:publicationType |
Journal Article
|