| pubmed-article:9367744 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9367744 | lifeskim:mentions | umls-concept:C0162638 | lld:lifeskim |
| pubmed-article:9367744 | lifeskim:mentions | umls-concept:C0040711 | lld:lifeskim |
| pubmed-article:9367744 | lifeskim:mentions | umls-concept:C0035696 | lld:lifeskim |
| pubmed-article:9367744 | lifeskim:mentions | umls-concept:C0080124 | lld:lifeskim |
| pubmed-article:9367744 | lifeskim:mentions | umls-concept:C1148846 | lld:lifeskim |
| pubmed-article:9367744 | lifeskim:mentions | umls-concept:C1444748 | lld:lifeskim |
| pubmed-article:9367744 | lifeskim:mentions | umls-concept:C1511695 | lld:lifeskim |
| pubmed-article:9367744 | lifeskim:mentions | umls-concept:C1709694 | lld:lifeskim |
| pubmed-article:9367744 | lifeskim:mentions | umls-concept:C0678594 | lld:lifeskim |
| pubmed-article:9367744 | lifeskim:mentions | umls-concept:C1481608 | lld:lifeskim |
| pubmed-article:9367744 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:9367744 | pubmed:dateCreated | 1997-12-5 | lld:pubmed |
| pubmed-article:9367744 | pubmed:abstractText | The hok/sok locus of plasmid R1 mediates plasmid stabilization by killing of plasmid-free cells. The locus specifies two RNAs, hok mRNA and Sok antisense RNA. The post-segregational killing mediated by hok/sok is governed by a complicated control mechanism that involves both post-transcriptional inhibition of translation by Sok-RNA and activation of hok translation by mRNA 3' processing. Sok-RNA inhibits translation of a reading frame (mok) that overlaps with hok, and translation of hok is coupled to translation of mok. In the inactive full-length hok mRNA, the translational activator element at the mRNA 5'-end (tac) is sequestered by the fold-back-inhibitory element located at the mRNA 3'-end (fbi). The 5' to 3' pairing locks the RNA in an inert configuration in which the SDmok and Sok-RNA target regions are sequestered. Here we show that the 3' processing leads to major structural rearrangements in the mRNA 5'-end. The structure of the refolded RNA explains activation of translation and antisense RNA binding. The refolded RNA contains an antisense RNA target stem-loop that presents the target nucleotides in a single-stranded conformation. The stem of the target hairpin contains SDmok and AUGmok in a paired configuration. Using toeprinting analysis, we show that this pairing keeps SDmok in an accessible configuration. Furthermore, a mutational analysis shows that an internal loop in the target stem is prerequisite for efficient translation and antisense RNA binding. | lld:pubmed |
| pubmed-article:9367744 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9367744 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9367744 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:9367744 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9367744 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:9367744 | pubmed:issn | 0022-2836 | lld:pubmed |
| pubmed-article:9367744 | pubmed:author | pubmed-author:GerdesKK | lld:pubmed |
| pubmed-article:9367744 | pubmed:author | pubmed-author:GultyaevA PAP | lld:pubmed |
| pubmed-article:9367744 | pubmed:author | pubmed-author:FranchTT | lld:pubmed |
| pubmed-article:9367744 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9367744 | pubmed:day | 17 | lld:pubmed |
| pubmed-article:9367744 | pubmed:volume | 273 | lld:pubmed |
| pubmed-article:9367744 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9367744 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9367744 | pubmed:pagination | 38-51 | lld:pubmed |
| pubmed-article:9367744 | pubmed:dateRevised | 2007-11-15 | lld:pubmed |
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| pubmed-article:9367744 | pubmed:year | 1997 | lld:pubmed |
| pubmed-article:9367744 | pubmed:articleTitle | Programmed cell death by hok/sok of plasmid R1: processing at the hok mRNA 3'-end triggers structural rearrangements that allow translation and antisense RNA binding. | lld:pubmed |
| pubmed-article:9367744 | pubmed:affiliation | Department of Molecular Biology, Odense University, Denmark. | lld:pubmed |
| pubmed-article:9367744 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:9367744 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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