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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2
|
| pubmed:dateCreated |
1997-12-2
|
| pubmed:abstractText |
Chronic periodontitis is characterized by dense infiltrations of T lymphocytes in the connective tissue, which consists mainly of gingival fibroblasts. It is becoming increasingly clear that T lymphocytes and gingival fibroblasts are capable of influencing each other. For example, the T cell cytokine interferon-gamma (IFN-gamma) is able to induce MHC class II molecules on the surface of several cell types, including gingival fibroblasts. Histological sections of chronically inflamed gingival tissue showed a great number of CD4+ and CD8+ T cells that produced IFN-gamma, and in addition showed abundant expression of MHC class II molecules on gingival fibroblasts. Therefore, we investigated whether these gingival fibroblasts acquire the capacity to carry out MHC class II-restricted functions such as antigen presentation to local T cells. In this study, we show that IFN-gamma-treated gingival fibroblasts were able to function as antigen-presenting cells (APC) for superantigen-mediated T cell proliferation. However, these fibroblasts failed to present whole-cell antigens of periodontitis-associated bacteria. Moreover, gingival fibroblasts inhibited the presentation of the whole-cell antigens of these bacteria by professional APC. This inhibition could be overcome by the addition of IL-2. These results suggest that gingival fibroblasts play an important role in the local specific immune response in chronic inflammatory periodontal lesions by regulating the response of infiltrating T cells.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Nov
|
| pubmed:issn |
0009-9104
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
110
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
277-84
|
| pubmed:dateRevised |
2008-11-21
|
| pubmed:meshHeading |
pubmed-meshheading:9367413-Adult,
pubmed-meshheading:9367413-Antigen Presentation,
pubmed-meshheading:9367413-CD4-Positive T-Lymphocytes,
pubmed-meshheading:9367413-CD8-Positive T-Lymphocytes,
pubmed-meshheading:9367413-Chronic Disease,
pubmed-meshheading:9367413-Fibroblasts,
pubmed-meshheading:9367413-Gingiva,
pubmed-meshheading:9367413-Histocompatibility Antigens Class II,
pubmed-meshheading:9367413-Humans,
pubmed-meshheading:9367413-Interferon-gamma,
pubmed-meshheading:9367413-Periodontitis,
pubmed-meshheading:9367413-Superantigens
|
| pubmed:year |
1997
|
| pubmed:articleTitle |
Antigen-presenting properties of gingival fibroblasts in chronic adult periodontitis.
|
| pubmed:affiliation |
Laboratory of Cell Biology and Histology, Academic Medical Centre, University of Amsterdam, The Netherlands.
|
| pubmed:publicationType |
Journal Article
|