Linked Life Data

9367243

Source:http://linkedlifedata.com/resource/pubmed/id/9367243

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1-2
pubmed:dateCreated
1998-1-5
pubmed:abstractText
One of the earliest histopathological changes associated with age-related hearing loss appears to be the disruption of outer hair cells (OHCs). To evaluate age-related changes in OHC function, distortion product otoacoustic emissions (DPOAEs) were recorded in the young and aging C57BL/6J mouse. Starting in young adulthood, the C57 mouse displays age-related elevation of auditory brainstem response thresholds, beginning in the high frequencies and progressing toward lower frequencies. The 2f1-f2 DPOAEs of mice between 2 and 20 months of age were examined for f2s between 8 and 16 kHz. In this octave region, the features of 2f1-f2 DPOAEs in the 2-month-old C57 mouse were comparable to those described for non-murine rodents in the literature in terms of optimum f2/f1 ratio, optimum primary level difference, input/output (I/O) function features and microstructure. It was determined that f2/f1 = 1.2 and L1-L2 = 20 dB were optimal stimulus parameters for investigation of the effects of age on C57 DPOAEs. Age-related changes in DPOAE I/O functions consisted of a right shift (i.e. increased DPOAE detection thresholds), disappearance of 'notches' and shallowing of the slopes after 8 months of age. As DPOAE I/O functions continued to shift to the right and DPOAE levels decreased with age, the appearance of I/O functions became complex to include regions of steep or shallow slopes and plateaus. The present results suggest that the age-related elevation of auditory thresholds in the C57 mice is associated with substantial progressive changes in OHC function.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
0378-5955
pubmed:author
pubmed:issnType
Print
pubmed:volume
112
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
216-34
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1997
pubmed:articleTitle
Distortion product otoacoustic emissions in the C57BL/6J mouse model of age-related hearing loss.
pubmed:affiliation
Department of Surgery, The School of Medicine, University of Connecticut Health Center, Farmington 06030-1110, USA. parham@neuron.uchc.edu
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't