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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
7
|
| pubmed:dateCreated |
1997-12-30
|
| pubmed:abstractText |
We have established a system for recovering Sendai virus (SeV), a nonsegmented negative strand RNA virus, entirely from cDNA at an extremely high rate, and have succeeded in creating a V(-) SeV whose gene expression was greatly enhanced by the deletion of the nonessential V gene. Because of its extreme medical importance, there has been a strong need for the establishment of a better system to express the gp120 envelope glycoprotein of the human immunodeficiency virus type 1 (HIV-1) in sufficient quantity and purity. It also remains to be established to produce gp120 in in vitro natural host cells for HIV-1 such as human primary blood mononuclear cells, macrophages or established T cell lines.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jul
|
| pubmed:issn |
1356-9597
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
2
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
457-66
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:9366551-DNA, Recombinant,
pubmed-meshheading:9366551-Gene Expression,
pubmed-meshheading:9366551-Genetic Vectors,
pubmed-meshheading:9366551-HIV Envelope Protein gp120,
pubmed-meshheading:9366551-Humans,
pubmed-meshheading:9366551-Plasmids,
pubmed-meshheading:9366551-Recombinant Fusion Proteins,
pubmed-meshheading:9366551-Respirovirus
|
| pubmed:year |
1997
|
| pubmed:articleTitle |
Sendai virus-based expression of HIV-1 gp120: reinforcement by the V(-) version.
|
| pubmed:affiliation |
Department of Viral Infection, Institute of Medical Science, University of Tokyo, Japan.
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|