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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
5
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pubmed:dateCreated |
1997-12-1
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pubmed:abstractText |
The mu opioid receptor (MuOR) is a member of the superfamily of G protein-coupled receptors that mediates the analgesic actions of endogenous opioid peptides and the narcotic alkaloid derivatives of morphine. Activation and translocation of protein kinase C (PKC) by N-methyl-D-aspartate receptor stimulation correlates with resistance to opioid drugs in experimental states of neuropathic pain, but the cellular mechanisms of resistance have not been identified. One possibility is that PKC activation regulates MuOR mRNA expression and thus the ability to generate functional receptors. Using a human neuroblastoma cell line, the authors tested the hypothesis that phorbol ester activation of PKC regulates MuOR mRNA levels.
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pubmed:commentsCorrections | |
pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
AIM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0003-3022
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
87
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1127-38
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pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:9366465-Enzyme Activation,
pubmed-meshheading:9366465-Gene Expression Regulation,
pubmed-meshheading:9366465-Humans,
pubmed-meshheading:9366465-Neuroblastoma,
pubmed-meshheading:9366465-Protein Kinase C,
pubmed-meshheading:9366465-RNA, Messenger,
pubmed-meshheading:9366465-Receptors, Opioid, mu,
pubmed-meshheading:9366465-Tetradecanoylphorbol Acetate,
pubmed-meshheading:9366465-Transcription, Genetic,
pubmed-meshheading:9366465-Transfection,
pubmed-meshheading:9366465-Tumor Cells, Cultured
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pubmed:year |
1997
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pubmed:articleTitle |
Regulation of mu opioid receptor mRNA levels by activation of protein kinase C in human SH-SY5Y neuroblastoma cells.
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pubmed:affiliation |
Department of Anesthesia and Critical Care, Massachusetts General Hospital, Harvard Medical School, Boston 02114-2696, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, Non-P.H.S.
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