| pubmed-article:9366401 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9366401 | lifeskim:mentions | umls-concept:C0011306 | lld:lifeskim |
| pubmed-article:9366401 | lifeskim:mentions | umls-concept:C1704410 | lld:lifeskim |
| pubmed-article:9366401 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:9366401 | pubmed:issue | 10 | lld:pubmed |
| pubmed-article:9366401 | pubmed:dateCreated | 1997-11-25 | lld:pubmed |
| pubmed-article:9366401 | pubmed:abstractText | Dendritic cells (DC) form a specialized system for presenting Ag to naive or quiescent T cells and consequently play a central role in the induction of T and B cell immunity. In this study we used DC generated from peripheral progenitors to analyze the effect of IL-10 on the accessory function of human DC. We demonstrate that immature DC, harvested on days 9 to 11 and exposed to IL-10 for the last 2 days of culture, show a strongly reduced capacity to stimulate a CD4+ T cell response in an allogeneic MLR in a dose-dependent manner. In contrast, fully mature DC are completely resistant to the effects of IL-10. These results were obtained in both an alloantigen-induced MLR and an anti-CD3 mAb-induced response of primed and naive (CD45RA+) CD4+ T cells. FACS analysis revealed inhibition of the up-regulation of the costimulatory molecules CD58 and CD86 and the specific DC marker CD83 in DC pretreated with IL-10. These data suggest that IL-10 inhibited the development of fully mature DC. Furthermore, DC precultured with IL-10, but not controls, induced a state of alloantigen-specific anergy in CD4+ T cells and of peptide-specific anergy in the influenza hemagglutinin-specific T cell clone HA1.7. Analysis of the supernatants of these anergic T cells revealed a reduced production of IL-2 and IFN-gamma compared with that in control cells. Collectively, these data suggest that IL-10 converts immature DC into tolerogenic APC, which might be a useful tool in the therapy of patients with autoimmune or allergic diseases. | lld:pubmed |
| pubmed-article:9366401 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9366401 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9366401 | pubmed:citationSubset | AIM | lld:pubmed |
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| pubmed-article:9366401 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9366401 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:9366401 | pubmed:issn | 0022-1767 | lld:pubmed |
| pubmed-article:9366401 | pubmed:author | pubmed-author:KnoxBB | lld:pubmed |
| pubmed-article:9366401 | pubmed:author | pubmed-author:SteinbrinkKK | lld:pubmed |
| pubmed-article:9366401 | pubmed:author | pubmed-author:EnkA HAH | lld:pubmed |
| pubmed-article:9366401 | pubmed:author | pubmed-author:JonuleitHH | lld:pubmed |
| pubmed-article:9366401 | pubmed:author | pubmed-author:WölflMM | lld:pubmed |
| pubmed-article:9366401 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9366401 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:9366401 | pubmed:volume | 159 | lld:pubmed |
| pubmed-article:9366401 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9366401 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9366401 | pubmed:pagination | 4772-80 | lld:pubmed |
| pubmed-article:9366401 | pubmed:dateRevised | 2007-11-15 | lld:pubmed |
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| pubmed-article:9366401 | pubmed:year | 1997 | lld:pubmed |
| pubmed-article:9366401 | pubmed:articleTitle | Induction of tolerance by IL-10-treated dendritic cells. | lld:pubmed |
| pubmed-article:9366401 | pubmed:affiliation | Department of Dermatology, University of Mainz, Germany. | lld:pubmed |
| pubmed-article:9366401 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:9366401 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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