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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
21
|
| pubmed:dateCreated |
1997-12-19
|
| pubmed:abstractText |
In this paper, we look at the incidence and predictive factors of pre-AIDS mortality among HIV-infected individuals, and injecting drug users (IDUs) in particular, and compare IDUs with non-IDUs. 627 patients (73 per cent IDUs) of the Edinburgh City Hospital HIV Cohort were enrolled pre-AIDS and followed up until September 1994. Analyses were performed using cumulative hazard and cumulative incidence estimators for a competing risks model, the Cox proportional hazards model and the non-parametric hazard estimator of Fusaro et al. (1993). The effects of age and CD4 T-lymphocyte cell count, progressively depleted during HIV progression, were investigated. 60 deaths occurred in AIDS-free patients during follow-up; 25 were drug-related deaths in IDUs. Pre-AIDS mortality was higher among IDUs than non-IDUs (p = 0.07). The cumulative incidences of pre-AIDS death after five years from enrollment were 11 per cent in IDUs and 6 per cent in non-IDUs; the cumulative AIDS incidences were, respectively, 19 per cent and 32 per cent. After eight years, cumulative pre-AIDS death incidence was 15 per cent among IDUs; cumulative AIDS incidence among IDUs was 35 per cent. Both groups had similar risks of medically-related (non-AIDS)-MRNA-death. Age and CD4 count were both individually predictive of MRNA death (relative risks (RRs); 2.1 per decade of life, p < 0.01; and 1.9 for each 100 cells per 100 microliters lost, p < 0.0001), although when used together age was less significant (RR 1.6, p = 0.07). Neither was statistically significant for drug-related mortality, although hazard may be lower in older individuals and may increase with falling CD4 count. The drug-related mortality was 1.1 per cent: 2.3 per cent in the first two years after enrollment, and 0.4 per cent thereafter. We conclude that older HIV-infected individuals are at greater risk of medically-related death before AIDS. This risk increases as CD4 count declines. Drug-related hazard may be greater in younger individuals and may increase as CD4 counts fall, but neither effect was formally significant.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Nov
|
| pubmed:issn |
0277-6715
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
15
|
| pubmed:volume |
16
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
2459-74
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:9364654-Acquired Immunodeficiency Syndrome,
pubmed-meshheading:9364654-Adult,
pubmed-meshheading:9364654-Age Factors,
pubmed-meshheading:9364654-CD4 Lymphocyte Count,
pubmed-meshheading:9364654-Cohort Studies,
pubmed-meshheading:9364654-Female,
pubmed-meshheading:9364654-HIV Infections,
pubmed-meshheading:9364654-Hospitals, Urban,
pubmed-meshheading:9364654-Humans,
pubmed-meshheading:9364654-Incidence,
pubmed-meshheading:9364654-Male,
pubmed-meshheading:9364654-Proportional Hazards Models,
pubmed-meshheading:9364654-Regression Analysis,
pubmed-meshheading:9364654-Risk Factors,
pubmed-meshheading:9364654-Scotland,
pubmed-meshheading:9364654-Substance Abuse, Intravenous,
pubmed-meshheading:9364654-Time Factors
|
| pubmed:year |
1997
|
| pubmed:articleTitle |
Pre-AIDS mortality in the Edinburgh City Hospital HIV cohort.
|
| pubmed:affiliation |
Medical Research Council Biostatistics Unit, Institute of Public Health, Cambridge, U.K.
|
| pubmed:publicationType |
Journal Article,
Comparative Study
|