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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
21
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pubmed:dateCreated |
1997-11-25
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pubmed:abstractText |
When given during pregnancy, the drug 3'-azido-2',3'-dideoxythymidine (AZT) substantially reduces maternal-fetal transmission of human immunodeficiency virus type 1 (HIV-1). However, AZT has been shown to be carcinogenic in adult mice after lifetime oral administration. In this study, we assessed the transplacental tumorigenic and genotoxic effects of AZT in the offspring of CD-1 mice and Erythrocebus patas monkeys given AZT orally during pregnancy.
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0027-8874
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pubmed:author |
pubmed-author:AndersonL MLM,
pubmed-author:DiwanB ABA,
pubmed-author:HainesD CDC,
pubmed-author:HarbaughS WSW,
pubmed-author:JonesA BAB,
pubmed-author:LogsdonDD,
pubmed-author:MoskalT JTJ,
pubmed-author:OliveroO AOA,
pubmed-author:PoirierM CMC,
pubmed-author:RiceJ MJM,
pubmed-author:RiggsC WCW,
pubmed-author:YuspaS HSH
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pubmed:issnType |
Print
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pubmed:day |
5
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pubmed:volume |
89
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1602-8
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pubmed:dateRevised |
2003-11-14
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pubmed:meshHeading |
pubmed-meshheading:9362158-Animals,
pubmed-meshheading:9362158-Animals, Newborn,
pubmed-meshheading:9362158-Carcinogens,
pubmed-meshheading:9362158-DNA, Mitochondrial,
pubmed-meshheading:9362158-DNA, Neoplasm,
pubmed-meshheading:9362158-Dose-Response Relationship, Drug,
pubmed-meshheading:9362158-Erythrocebus patas,
pubmed-meshheading:9362158-Female,
pubmed-meshheading:9362158-Fetus,
pubmed-meshheading:9362158-Mice,
pubmed-meshheading:9362158-Mice, Inbred Strains,
pubmed-meshheading:9362158-Placenta,
pubmed-meshheading:9362158-Pregnancy,
pubmed-meshheading:9362158-Radioimmunoassay,
pubmed-meshheading:9362158-Telomere,
pubmed-meshheading:9362158-Zidovudine
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pubmed:year |
1997
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pubmed:articleTitle |
Transplacental effects of 3'-azido-2',3'-dideoxythymidine (AZT): tumorigenicity in mice and genotoxicity in mice and monkeys.
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pubmed:affiliation |
Division of Basic Sciences, National Cancer Institute, Bethesda, MD 20892-4255, USA. olivero@pop.nci.nih.gov
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pubmed:publicationType |
Journal Article
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