| pubmed-article:9361351 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9361351 | lifeskim:mentions | umls-concept:C0205054 | lld:lifeskim |
| pubmed-article:9361351 | lifeskim:mentions | umls-concept:C0020649 | lld:lifeskim |
| pubmed-article:9361351 | lifeskim:mentions | umls-concept:C0017755 | lld:lifeskim |
| pubmed-article:9361351 | lifeskim:mentions | umls-concept:C0333275 | lld:lifeskim |
| pubmed-article:9361351 | lifeskim:mentions | umls-concept:C0035273 | lld:lifeskim |
| pubmed-article:9361351 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:9361351 | lifeskim:mentions | umls-concept:C1515926 | lld:lifeskim |
| pubmed-article:9361351 | pubmed:issue | 5 | lld:pubmed |
| pubmed-article:9361351 | pubmed:dateCreated | 1998-1-6 | lld:pubmed |
| pubmed-article:9361351 | pubmed:abstractText | The mRNA abundance of several hepatic glycolytic and gluconeogenic enzymes and blood hormone concentrations were determined in hemorrhagic hypotension-induced rats before and after resuscitation with lactated Ringer's. Northern blot analysis of total liver RNA after 30 min of hemorrhage showed control values for phospho-enolpyruvate carboxykinase and fructose-1,6-bisphosphatase mRNA, but significantly lower values for 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase (6PF2K/FBPase) as well as 2.5-fold increases in glucose-6-phosphatase (Glu-6-Pase) mRNA. The latter finding is in agreement with the greatly reduced intracellular levels of fructose-6-phosphate and glucose-6-phosphate, and the results are consistent with a rapid activation of hepatic gluconeogenesis by the concomitant decrease in 6PF2K/FBPase and increase in Glu-6-Pase. Blood insulin levels were decreased during hemorrhage and with resuscitation, whereas glucocorticoids were increased 1.5-fold in both cases. Glucagon was unchanged during hemorrhage, but was reduced with resuscitation. Lactated Ringer's resuscitation seemed to affect 6PF2K/FBPase only, which was restored to, and even exceeded, control values. In contrast, Glu-6-Pase mRNA was increased to fourfold control values. The increase in Glu-6-Pase and the decrease in 6PF2K/FBPase mRNA is probably at the level of altered transcriptional rates, because insulin, which plays a dominant role in the regulation of these genes, was decreased during hemorrhage. It remains to be determined what factors are causing further induction of Glu-6-Pase gene after lactated Ringer's resuscitation when hepatic glucose metabolism seems to have reverted to the glycolytic mode. | lld:pubmed |
| pubmed-article:9361351 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9361351 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9361351 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9361351 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9361351 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:9361351 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:9361351 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9361351 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9361351 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9361351 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9361351 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9361351 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9361351 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:9361351 | pubmed:issn | 1073-2322 | lld:pubmed |
| pubmed-article:9361351 | pubmed:author | pubmed-author:MaitraS RSR | lld:pubmed |
| pubmed-article:9361351 | pubmed:author | pubmed-author:el-MaghrabiM... | lld:pubmed |
| pubmed-article:9361351 | pubmed:author | pubmed-author:GestringMM | lld:pubmed |
| pubmed-article:9361351 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9361351 | pubmed:volume | 8 | lld:pubmed |
| pubmed-article:9361351 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9361351 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9361351 | pubmed:pagination | 385-8 | lld:pubmed |
| pubmed-article:9361351 | pubmed:dateRevised | 2011-11-17 | lld:pubmed |
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| pubmed-article:9361351 | pubmed:year | 1997 | lld:pubmed |
| pubmed-article:9361351 | pubmed:articleTitle | Alterations in hepatic 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase and glucose-6-phosphatase gene expression after hemorrhagic hypotension and resuscitation. | lld:pubmed |
| pubmed-article:9361351 | pubmed:affiliation | Department of Emergency Medicine, University Medical Center, Stony Brook, NY 11794-8191, USA. | lld:pubmed |
| pubmed-article:9361351 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:9361351 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:9361351 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9361351 | lld:pubmed |
