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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
11
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pubmed:dateCreated |
1997-12-9
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pubmed:abstractText |
HIV-specific mucosal and cellular immunity was analyzed in heterosexual couples discordant for HIV status in serum and in HIV-unexposed controls. HIV-specific IgA but not IgG was present in urine and vaginal wash samples from HIV-exposed seronegative individuals (ESN), whereas both IgA and IgG were observed in their HIV-seropositive partners; antibodies were not detected in low-risk controls. Envelope protein (Env) peptide-stimulated interleukin-2 (IL-2) production by peripheral blood mononuclear cells (PBMCs) was detected in 9 out of 16 ESNs, 5 out of 16 HIV-infected patients and 1 out of 50 controls. Env peptide-stimulated PBMCs of ESNs produced more IL-2 and less IL-10 compared with those of HIV-infected individuals; no differences were observed in chemokine production or in CCR5 expression. These data demonstrate that a compartmentalized immune response to pathogens is possible in humans and raise the possibility of protective roles for cell-mediated immunity and mucosal IgA in HIV-seronegative individuals exposed to HIV.
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Chemokines, CC,
http://linkedlifedata.com/resource/pubmed/chemical/DNA, Complementary,
http://linkedlifedata.com/resource/pubmed/chemical/Gene Products, env,
http://linkedlifedata.com/resource/pubmed/chemical/Immunoglobulin A,
http://linkedlifedata.com/resource/pubmed/chemical/Immunoglobulin G,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-2,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Viral,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, CCR5
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
1078-8956
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pubmed:author |
pubmed-author:BiasioLL,
pubmed-author:BorYY,
pubmed-author:ClericiMM,
pubmed-author:FusiM LML,
pubmed-author:Lo CaputoSS,
pubmed-author:LonghiRR,
pubmed-author:MazzoliSS,
pubmed-author:MazzottaFF,
pubmed-author:MeacciFF,
pubmed-author:PiconiSS,
pubmed-author:RuzzanteSS,
pubmed-author:SalvoGG,
pubmed-author:SempliciFF,
pubmed-author:TofaniNN,
pubmed-author:TrabattoniDD,
pubmed-author:VillaM LML
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pubmed:issnType |
Print
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pubmed:volume |
3
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1250-7
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:9359700-Adult,
pubmed-meshheading:9359700-Blotting, Western,
pubmed-meshheading:9359700-Chemokines, CC,
pubmed-meshheading:9359700-DNA, Complementary,
pubmed-meshheading:9359700-Female,
pubmed-meshheading:9359700-Gene Products, env,
pubmed-meshheading:9359700-HIV Seronegativity,
pubmed-meshheading:9359700-HIV Seropositivity,
pubmed-meshheading:9359700-HIV-1,
pubmed-meshheading:9359700-Heterosexuality,
pubmed-meshheading:9359700-Humans,
pubmed-meshheading:9359700-Immunity, Cellular,
pubmed-meshheading:9359700-Immunity, Mucosal,
pubmed-meshheading:9359700-Immunoglobulin A,
pubmed-meshheading:9359700-Immunoglobulin G,
pubmed-meshheading:9359700-Interleukin-2,
pubmed-meshheading:9359700-Male,
pubmed-meshheading:9359700-Middle Aged,
pubmed-meshheading:9359700-RNA, Viral,
pubmed-meshheading:9359700-Receptors, CCR5,
pubmed-meshheading:9359700-Sexual Partners,
pubmed-meshheading:9359700-Vagina
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pubmed:year |
1997
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pubmed:articleTitle |
HIV-specific mucosal and cellular immunity in HIV-seronegative partners of HIV-seropositive individuals.
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pubmed:affiliation |
Centro M.S.T./U.O. Malattie Infettive, Ospedale S.M. Annunziata, Florence, Italy.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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