Linked Life Data

9359658

Source:http://linkedlifedata.com/resource/pubmed/id/9359658

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
16
pubmed:dateCreated
1998-1-9
pubmed:abstractText
Relationships were sought between specific anti-HIV cytotoxic T lymphocyte (CTL) responses (against structural and regulatory proteins of the HIV-1 LAI isolate) and plasma and cellular viral loads (VLs) in 17 recently HIV-1-infected patients including 3 displaying asymptomatic primary infection (PI) followed up for 12 months. Plasma VL was correlated directly with CD8 counts and inversely with CD4 counts. Cytotoxic reactions were observed in all patients and directed mainly against structural proteins. The earliest CTL responses were against Gag and Env proteins detected in 87 and 75% of the subjects, respectively, within the first month following PI. Anti-Env and Gag cytotoxic responses were inversely correlated with the plasma VL. Reactions against the pol gene products were thought to be either less involved in or less efficient for the initial decrease of viremia. Responses against regulatory gene products were weak and variable, apart from Nef, which was recognized by half of the subjects. Neutralizing antibodies were not detected before month 3, and were found only in six patients at subsequent times. Two of three patients with asymptomatic PI had a low viral burden and either a delayed response or one limited to a few protein CTL responses, suggesting that the magnitude of the CTL response depends on the initial plasma VL. The third patient displayed viral and CTL parameters identical to those of the patients with symptomatic PI. However, two subjects with symptomatic PI exhibited similarly low plasma VL and moderate CTL responses. Overall, the results suggest that the CTL response may not be the sole factor controlling viremia.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
0889-2229
pubmed:author
pubmed:issnType
Print
pubmed:day
1
pubmed:volume
13
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1383-94
pubmed:dateRevised
2007-11-15
pubmed:meshHeading
pubmed-meshheading:9359658-Acquired Immunodeficiency Syndrome, pubmed-meshheading:9359658-Adult, pubmed-meshheading:9359658-CD4-Positive T-Lymphocytes, pubmed-meshheading:9359658-CD8-Positive T-Lymphocytes, pubmed-meshheading:9359658-Cytotoxicity, Immunologic, pubmed-meshheading:9359658-Female, pubmed-meshheading:9359658-Follow-Up Studies, pubmed-meshheading:9359658-Gene Products, env, pubmed-meshheading:9359658-Gene Products, nef, pubmed-meshheading:9359658-Genes, Viral, pubmed-meshheading:9359658-HIV Antibodies, pubmed-meshheading:9359658-HIV Seropositivity, pubmed-meshheading:9359658-HIV-1, pubmed-meshheading:9359658-Humans, pubmed-meshheading:9359658-Male, pubmed-meshheading:9359658-Middle Aged, pubmed-meshheading:9359658-Neutralization Tests, pubmed-meshheading:9359658-RNA, Viral, pubmed-meshheading:9359658-T-Lymphocytes, Cytotoxic, pubmed-meshheading:9359658-Time Factors, pubmed-meshheading:9359658-Viral Structural Proteins, pubmed-meshheading:9359658-nef Gene Products, Human Immunodeficiency Virus
pubmed:year
1997
pubmed:articleTitle
Course of specific T lymphocyte cytotoxicity, plasma and cellular viral loads, and neutralizing antibody titers in 17 recently seroconverted HIV type 1-infected patients.
pubmed:affiliation
INSERM U328, Structure et Fonctions des Retrovirus Humains, Laboratoire de Virologie de l'Université Victor Ségalen Bordeaux 2, France.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, Non-U.S. Gov't