Linked Life Data

9357068

Source:http://linkedlifedata.com/resource/pubmed/id/9357068

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
7
pubmed:dateCreated
1998-1-5
pubmed:abstractText
Reports of the action of gastrin-releasing peptide (GRP) on gallbladder contraction are limited to a few species. We compared the action of GRP, acetyl gastrin-releasing peptide 20-27 (GRP 20-27), and cholecystokinin-octapeptide (CCK-8) on gallbladder contractility with and without pretreatment with the neural inhibitor tetrodotoxin (TTX) and the bombesin antagonist [D-Phe 6, Des-Met 14]-bombesin 6-14 ethylamide (BBS 6-14 E). Full-thickness muscle strips were prepared and suspended in organ baths. The maximum GRP, GRP 20-27, and CCK-8 responses were 54.2 +/- 4.2%, 74.6 +/- 6.4%, and 69.3 +/- 6.9% of that of carbachol, respectively. Pretreatment with TTX influenced the action of GRP 20-27, and pretreatment with BBS 6-14 E influenced that of GRP and GRP 20-27. These studies show that GRP and GRP 20-27 are potent agonists of gallbladder contractility, acting via GRP-preferring receptors, and that GRP 20-27 also acts via a neural component.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0196-9781
pubmed:author
pubmed:issnType
Print
pubmed:volume
18
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1067-71
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1997
pubmed:articleTitle
Gastrin-releasing peptide stimulates possum gallbladder contractility in vitro.
pubmed:affiliation
Department of Surgery, Flinders Medical Centre, Bedford Park, South Australia, Australia.
pubmed:publicationType
Journal Article, In Vitro, Research Support, Non-U.S. Gov't